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Structural Characteristics and Immunological Activity of Glycosaminoglycan RG-1 from Ruditapes Philippinarum

Fan Xiuping Wang Ruifang Wu Hongmian Wang Yanan Hu Xueqiong Lei Xiaolin (School of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524006,Guangdong)  
Objective:To investigate the structural characterstics and cells immunomodulatory activity of the glycosaminoglycan RG-1 from Ruditapes philippinarum.Methods:The morlicular weight and monosaccharide composition of the glycosaminoglycan RG-1 was analysed by HPGPC,its main structure characterstics was studied by IR,periodate oxidation and Smith degradation.Effects of RG-1 on proliferation of KM mouse spleen lymphocytes were detected by MTT.Results:RG-1 was composed of Glc-GalNAc-Gal by 1→6,1→4 or 1→4,6 in main chain backbone which contained much galacturonic acid with Mr 9.94×105.RG-1 significantly simulated the phagocytic activity of mice peritoneal macrophages and proliferation of KM mouse spleen lymphocytes in vitro (p0.01).Conclusion:N Glycosaminoglycan RG-1 can inhibit the cancer by enhance cell immunological activity.
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