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《Veterinary Science in China》 2006-02
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Effect of aminoguanidin on liver mitochondrial free radical metabolism in broilers with endotoxemia

WANG You-ling~(1),ZHANG Sheng~(2),TANG Zhao-xin~(2) (1.Research Institute of Poultry Science,Shandong Academy of Agricultural Sciences,Jinan 250100,China;2.College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China)  
To explore effect of free radical on pathogenesis of endotoxemia in boilers,120 broilers were divided randomly into 4 groups of A,B,C and D with 30 in each group.Group A was normal control.Group B and C were injected intravenously with lipopolysaccharides(LPS) from Salmonella typhimurium and Group C was injected with aminoguanidine 1h before LPS injection.Group D was injected with only aminoguanidine.The liver mitochondrial T-AOC,T-SOD,GSH-Px,CAT activities and MDA content were examined at 1st,3rd,5th,7th and 9thh post-injection,respectively.Results revealed that MDA content of Group B increased gradually and after 5h it was significant compared with that of Group A.Activities of mitochondrial T-AOC,T-SOD,CAT,GSH-Px of Group B decreased gradually and activity of CAT was always evident in comparison with that of Group A,so was activity of GSH-Px after 5h.The activities of antioxidase of Group C improved much batter than that of Group B.The effect of aminoguanidine was obvious by comparing Group D with Group A.The experimental results showed that mitochondrial lipid peroxidation induced by endotoxin played an important role in endotoxemia of broilers,and(aminoguanidine) could reduce the injury and protect effectively mitochondrial functions and structure.
【Key Words】： aminoguanidine endotoxemia broilers mitochondrion free radical
【Fund】： 国家自然科学基金资助项目(300750574 30371068)
【CateGory Index】： S858.31
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