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《Veterinary Science in China》 2007-07
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Effect of aminoguanidine on liver free radical injury in broilers with endotoxemia

WANG You-ling1,TANG Zhao-xin2(1.Research Institute of Poultry Science,Shandong Academy of Agricultural Sciences,Jinan 250100,China;2.College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China)  
To explore the effect of free radical in the pathogenesis of endotoxemia in broilers,ninety 30-day old broilers were randomly divided into three groups of A,B and C with 30 each.Group A was the control with injection of normal saline solution.Groups B and Group C were intravenously injected with lipopolysaccharides from Salmonella typhimurium but Group C was intravenously injected with amino-guanidine one hour before injection of endotoxin.Six broiler livers were collected from every group.Activities of T-AOC,T-SOD,GSH-Px and CAT and content of MDA in the liver tissue were examined at different time points post-treatment.Content of MDA of Group B was increased gradually,and activities of T-AOC,T-SOD,CAT and GSH-Px of Group B were decreased gradually.The activities of antioxidase of Group C were improved much better than Group B.The results indicated that lipid perioxidation of liver tissue induced by endotoxin plays an important role in endotoxemia in broilers,and aminoguanidine can reduce this injury and effectively protect liver functions and structure.
【Key Words】： aminoguanidine broiler endotoxemia free radical liver
【Fund】： 国家自然科学基金资助项目(300750574 30371068)
【CateGory Index】： S858.31
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