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《Chinese Journal of Diabetes》 2003-03
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A study on relationship between human leucocyte antigen-DMA, DMB and genetic susceptibility of type 1 diabetes

SANG Yan-mei, YAN Chun, ZHU Cheng, et al. Beijng Children's Hospital Affiliated to Capital University of Medical Science, Beijng 100045, China  
Objective To study the relationship between human leucocyte antigen-DMA,DMB and genetic susceptibility of type 1 diabetes. Methods DNA were extracted from peripheral blood by routine techniques after which polymerase chain reaction and dot blot hybridization techniques were used to classify DMA and DMB alleles. Results DMA*0103 and DMB*0103 alleles were significantly increased in the patients,DMA*0102 and DMB*0101 alleles were significantly increased in the controls.DMA*0101/0102 and DMB*0101/0101 genotypes were significantly increased in the controls(42% vs 10.8%;46% vs 7.1%,respectively, P0.01), while DMB*0103/0103 and DMA*0101/0103 genotypes were significantly increased in the patients. DMA*0102/DMB*0101 heterodimer was significantly increased in the controls(28.6% vs 4.4%, P0.01), while DMA*0103/DMB*0102,DMA*0103/DMB*0103 and DMA*0103/DMB*0101 heterodimers were significantly increased in the patients. Conclusion DMA*0103 and DMB*0103 alleles are related with the susceptibility of type 1 diabetes in Chinese, while DMA*0102 and DMB*0101 alleles are related with the protection of type 1 diabetes. DMA*0101/0102 and DMB*0101/0101 genotypes contribute the protection,while DMB*0103/0103 and DMA*0101/0103 genotypes contribute susceptibility to type 1 diabetes in Chinese. DMA*0102/DMB*0101 heterodimer is related with the protection while DMA*0103/DMB*0102, DMA*0103/DMB*0103 and DMA*0103/DMB*0101 heterodimers are related with the susceptibility of type 1 diabetes in Chinese.
【Fund】: 北京市科委科技新星培养计划专项基金 ( 95 5 810 2 70 0 )
【CateGory Index】: R587.1
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Chinese Journal Full-text Database 1 Hits
1 WE Fei, HUANG Han-tin , HUANG Zhen-lie, LI Lai-yu , LIANG Li-yan , CHEN Xue-min . Department of Environmental Hygiene, Tongji medical College , Huazhong University of Science and Technology , Wuhan430030, China;Relationship of trichloroethylene-induced medicamentosa Uke dermatitis to HLA-DMA and HLA-DMB[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2006-05
Chinese Journal Full-text Database 1 Hits
1 Sang Yanmei,YanChun,Zhu Cheng,et al (Beijing Chidren’s Hospital,Affiliated toCapitalUniversity of Medicine,Beijing 100045);A combinedstudy on the relationship between HLA-DRB1andDQ alleles andthegeneticsusceptibility of IDDM[J];CHINESE JOURNAL OF DIABETES;1997-01
Chinese Journal Full-text Database 10 Hits
1 Zhang shu jie et al Mudanjiang Medical college 157011;Change of tumor necrosis factor (TNF)in serum on experimental diabetic rats[J];JOURNAL OF MUDANJIANG MEDICAL COLLEGE;2000-01
2 Zhang Shenglan,Ke Bingshen,Xing W anjia,et al. General Hospital of Jinan M ilitary Region,Jinan 250031,China;Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus[J];Qianwei Journal of Medicine;2001-05
3 XUE Fu-zhong, WANG Jie-zhen, HU Ping(Institute. of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China);Meta-analysis of the association of HLA-DR polymorphism with IDDM in Chinese population[J];Journal of Shandong Univenity(Health Scicnes);2004-05
4 Sang Yanmei,Yan Chun,Zhu Cheng,Ni Guichen,Hu Yamei(Department of Medicine,Beijing Children's Hospital,Capital University of Medical Sciences);The Association of HLA-DQA1,DMA,DMB Gene Polymorphism with Type 1 Diabetes[J];Journal of Capital University of Medical Sciences;2005-05
5 GONG Chunxiu, YAN Chun ,ZHU Cheng, et al . Beijing Children′s Hospital,Affiliated to the Capital University of Medical Sciences, Beijing 100045, P.R. China;Cytokines profile of different durations in type 1diabetes mellitus patients[J];Journal of Applied Clinical Pediatrics;2003-04
6 Liu Wei,Yao Zhi,Liu Yixin,et al Department of Endocrinology, General Hospital, Tianjin Medical University 300052;The Determination of IL-2/SIL-2R Levels and Their Significance in Patients with IDDM[J];Tianjing Medical Journal;1998-10
7 PANG Guo-xiang Department of Pediatrics CHEN Yu-hua WU Ge Endocrine branch,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China;Th1/Th2 cytokines in peripheral blood lymphocytes in patients with type 1 diabetes mellitus[J];Guide of China Medicine;2008-16
8 Zhang Huiying, Wang Binyou, Sun Jianhong, et al (Public Health College, Harbin Medical University, Harbin 150001);The study on the association of HLA-DQB1 alleles and type 1 diabetes in childhood[J];Chinese Journal of Diabetes;2001-05
9 XING Wanjia *,ZHANG Shenglan,KE Bingshen,et al. *Department of Endocrinology,General Hospital of Jinan Military Region,Jinan 250031;HLA-DPB1, DQB1 genes and their correlation with autoantibodies in type 1 diabetes mellitus[J];Chinese Journal of Endocrinology and Metabolism;2001-06
10 ZHANG Shenglan, XING Wanjia, KE Bing shen, YAN Hui, JIANG Zhaoshun. (General Hospital of Jinan Command, PLA, Jinan, Shando ng, 250031 P.R.China);Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus[J];Chinese Journal of Medical Genetics;2001-05
Chinese Journal Full-text Database 10 Hits
1 LU Wei 1, LI Xiang pei 2, SHI Xiao ming 1, XU Yuan yong 1, HU Yi song 1, YANG Shi gui 1, YE Dong qing 1. 1.Department of Epidemiology, Anhui Medical University, Hefei 230032, China; 2.Department of Rheumatism, Anhui Province Hospital, Hefei;The relationship of HLA-DM genetic polymorphisms with systemic lupus erythematosus in Chinese[J];Chinese Journal of Disease Control and Prevention;2002-02
2 ZHANG Hui-min(China Chlor-alkali Industry Association, Tianjin 300020, China);Production and application status of trichloroethylene[J];China Chlor-Alkali;2004-08
3 Fan Li-an et al.Shanghai Institute of Immunology;HLA AND INSULIN-DEPENDENT DIABETES MELLITUS[J];;1983-03
4 Xue Bin, et al. ( Department of Toxicology Beijing M edical Univrsity );A Modified MTT Colorimetric Assay for Measuring Lymphocyte Proliferation[J];Journal of Health Toxicology;1988-01
5 Dai Yu-fei, Nui Yong, Cheng Juan, Leng Shug-uang, et al. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050,China;The immunological effects in guinea pig sensitized by trichloroethylene[J];Journal of Hygiene Research;2005-01
6 LI Hong-mei 1,2 , ZHONG Ren-qian 1, YU Jia-ping 1, CAO Lu-ning 1, KO NG Xian-tao 1, CHEN Wei-feng 2 1 Department of Clinical Laboratory, Changzheng Hospital, Second Military Medical University, Shanghai 200003; 2Depertment of Immunology, Peking Univers ity Health Science Center, Beijing 100083, China;Defect of TCR-mediated signal pathway of Tcells in IDDM patients[J];Journal of Cellular and Molecular Immunology;2004-02
7 CHEN Wen, XU Lei, DENG Li xia, et al (School of Public Health, Sun Yat sen University of Medical Sciences, Guangzhou 510080, China);The effect of trichloroethylene on micronucleus formation in periphery lymphocytes of exposured workers[J];CHINESE OCCUPATIONAL MEDICINE;2000-05
8 LI Lai-yu 1, LENG Shu-guang 2, ZHENG Yu-xin 2, HE Jia-xi 3, HUANG Jian-xun 1, HE Feng-sheng 21. Hospital for Occupational Diseases Control of Guangdong Province P.R. of China; 2. Institute of Occupational Medicine, Chinese Academy of Preventive Medi;Trichloroethylene-induced medicamentosa-like dermatitis and genetic polymorphism of xenobiotics metabolic enzymes: a case-control study[J];Chinese Occupational Medicine;2002-03
9 LIANG Li-yan, LI Lai-yu, CHEN Run-tao, et al (Guangdong Prevention & Treatment Center for Occupational Diseases, Guangzhou 510300, China);Chromosome analysis on the medicamentosa-like dermatitis patients induced by trichloroethene[J];Chinese Occupational Medicine;2002-03
10 CHEN Xiao-yan, ZHUANG Zhi-xiong, HUANG Hai-xiong, et al (Post-doctoral Research Base in Shenzhen Center for Disease Control and Prevention, Post-doctoral Mobile Research Station of Sun Yat-sen University, Shenzhen 518020, China);Model of immuno-response elicited by trichloroethylene in SD rat[J];Chinese Occupational Medicine;2004-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Department of Clinical Microbiology and Immunology, Guiyang Medical College(Guiyang 550004) Jiang Hongmei Wang Yongxia;The linkage analysis of HLA-DRB_1 and polymorphisms of HLA-DM gene[J];Shaanxi Medical Journal;2008-09
2 HUANG Yong-shun1,2,HUANG Han-lin1;Research progress on immune injury resulted from occupational medicamentose-like dermatitis induced by trichloroethylene[J];China Occupational Medicine;2010-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhou Guo-yong;Xu Ai-hua;Wang Xiao-ning(Endocrine Section,Nanfang Hospital,the First Medical University of PLA,Guang Zhou 510515);The study of interleukin 2/interleukin 2 recepter system in insulin-dependent diabetes mellitus[J];CHINESE JOURNAL OF DIABETES;1995-04
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