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《Chinese Journal of Diabetes》 2003-03
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A study on relationship between human leucocyte antigen-DMA, DMB and genetic susceptibility of type 1 diabetes

SANG Yan-mei, YAN Chun, ZHU Cheng, et al. Beijng Children's Hospital Affiliated to Capital University of Medical Science, Beijng 100045, China  
Objective To study the relationship between human leucocyte antigen-DMA,DMB and genetic susceptibility of type 1 diabetes. Methods DNA were extracted from peripheral blood by routine techniques after which polymerase chain reaction and dot blot hybridization techniques were used to classify DMA and DMB alleles. Results DMA*0103 and DMB*0103 alleles were significantly increased in the patients,DMA*0102 and DMB*0101 alleles were significantly increased in the controls.DMA*0101/0102 and DMB*0101/0101 genotypes were significantly increased in the controls(42% vs 10.8%;46% vs 7.1%,respectively, P0.01), while DMB*0103/0103 and DMA*0101/0103 genotypes were significantly increased in the patients. DMA*0102/DMB*0101 heterodimer was significantly increased in the controls(28.6% vs 4.4%, P0.01), while DMA*0103/DMB*0102,DMA*0103/DMB*0103 and DMA*0103/DMB*0101 heterodimers were significantly increased in the patients. Conclusion DMA*0103 and DMB*0103 alleles are related with the susceptibility of type 1 diabetes in Chinese, while DMA*0102 and DMB*0101 alleles are related with the protection of type 1 diabetes. DMA*0101/0102 and DMB*0101/0101 genotypes contribute the protection,while DMB*0103/0103 and DMA*0101/0103 genotypes contribute susceptibility to type 1 diabetes in Chinese. DMA*0102/DMB*0101 heterodimer is related with the protection while DMA*0103/DMB*0102, DMA*0103/DMB*0103 and DMA*0103/DMB*0101 heterodimers are related with the susceptibility of type 1 diabetes in Chinese.
【Fund】: 北京市科委科技新星培养计划专项基金 ( 95 5 810 2 70 0 )
【CateGory Index】: R587.1
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