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《Chinese Journal of Diabetes》 2005-06
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Changes of CD_4~+CD_(25)~+ T cell subsets in LADA patients

HE Ling, ZHOU Zhi-guang, LUO Jian-hua, et al.Institute of Metabolism and Endocrinology, Xiangya 2nd Hospital, Central South University, Changsha 410011, China  
Objective To investigate the frequency and etiopathogenetic relevance of CD_4+ CD_ 25 + immunoregulatory T cells in latent autoimmune diabetes in adults (LADA). Methods Peripheral blood samples were obtained from patients with 32 LADA, 16 type 1 diabetes, 25 type 2 diabetes and 27 controls.The frequencies of peripheral CD _4 +CD _ 25 + double-positive, CD _3 +CD _8 + double-positive cells were measured by flowcytometry. Results ① We found lower numbers of CD _4 +CD _ 25 + T cells in LADA patients than those in T1DM, T2DM and control groups (0.71% vs 1.20%, 1.26%, 1.27%).② Higher frequencies of CD _3 +CD _8 + T cells were found in LADA group than in T1DM,T2DM and control ones (35.10% vs 24.40%, 23.55%, 22.15%).③ The frequency of CD _3 +CD _8 + T cells was negatively correlated with age at onset, fasting and postprandial C-peptides. Conclusions The frequency of CD _4 +CD _ 25 + T cells decreases in LADA patients, which cannot maintain the tolerance to islet autoantigens effectively.Cytotoxic CD _3 +CD _8 + T cells in the periphery blood simultaneously increase to attack and destroy islet β cells, leading to the development and progression of autoimmune diabetes.
【Fund】: 国家自然科学基金资助项目(30370681);; 教育部“跨世纪优秀人才”基金资助项目(2002-48);; 湖南省卫生厅重点资助项目(2001-Z04);; 湖南省科技厅重点资助项目(03SSY1009)
【CateGory Index】: R587.1
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