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《Chinese Journal of Natural Medicines》 2003-04
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Antitumor Effect of D-Glucosamine Hydrochloride in Mice

LI Yun-Man 1 ,TANG Ming-Yue 1 ,XIA Wen 2 ,LI Te 1 1 Department of Physiology,China Pharmaceutical Univer sity,Nanjing 210009; 2 Department of Blood,Jiangsu Province Hospital of Traditional Chine se Medicine,Nanjing 210009,China  
AIM: To study the antit umor effect of D-Glucosamine·HCl(D-GlcN·HCl) in tumor-bearing mice by ig route. MET HOD:Weight of tumor,peripheral leckocyte count,WBC /RBC ratio of marr ow cell an d body weight were used as index which was observed to evaluate the antitumor ef fect of D- GlcN·HCl. RESULT: The results showed that tumor inhibitory r ate of D-GlcN·HCl(20,10 mg/kg) on S 180 reached 66 .7% and 57.1% respectively. It could obviously prolong the survival days of mice with Heps. Surviva l p rolong rate of Heps-bearing mice reached 208.2% and 133.7% respectively by i g D- GlcN·HCl(20,10 mg/kg). It also had good inhibitory action of on the tumor wei ght of the mice with EC and had no inhibitory effect on peripheral leukocyte,WB C/RBC ratio of bone marrow and weights of tumor-bearing mice. CONCLUS IO N: This study showed that the inhibitory effect of D-GlcN·HCl on S 180 ,Heps and EC in mice was remarkable, and it had no obvious inhib itory a ction on peripheral leukocyte,WBC/RBC ratio of bone marrow and weights of tumor -bearing mice.
【CateGory Index】: R73-36
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