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《China Modern Medicine》 2009-19
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Clinical study of curative effect of oxiracetam injection on medium or serious brain injury

GUO Xiaofeng(The Peoples' Hospital of Xiangtan County,Hunan Province,Xiangtan 411100,China)  
Objective:To study and evaluate the efect of oxiracetam on medium or serious brain injury.Methods:Totally 126 patients with medium or serious rain injury were randomly assigned to receive oxiracetam or piracetam as control.NIHSS,MMSE and GCS scales were used to evaluate the therapeutic effects,as well as quantitative EEG.Results:The value of NIHSS,MMSE with a significant difference with the control group(P0.05).There was insignificant difference in GCS between both the groups.The significant improvement in qEEG was found in both groupsafter treatment(P0.05).The effect of oxiracetam on qEEG was more significant than that of paracetam(P0.05).Conclusion:Oxiracetam can better improve the neurological deficits and disturbances of memory and intelligence secondary to brain injury,can improve qEEG and the living quanlity.It deserves clinical research.
【CateGory Index】: R651.15
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Hai li bi nu er, WANG Yin hua, ZHAO Fa guo (Department of Neurology, The First Hospital of Peking University, BEIJING 100034, China);Randomized double-blind controlled study of oxiracetam vs piracetam in treatment of vascular dementia[J];Chinese Journal of New Drugs and Clinical Remedies;2003-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHU Kai, XI Gui-fa, NIU Hong-quan, DONG Zhen, YU Jia-sheng, LEI Ting, LI Ling. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, H uazhong University of Science and Technology, Wuhan 430030, China;Clinical evaluation of Oxiracetam in the treatment of craniocerebral trauma[J];Chinese Journal of Neuromedicine;2005-05
2 WA NG Ya-jie GAO Bao-qin YANG Wei-li. Department of Pediatrics,Beijing Tiantan Hospital,Capital University of Medical Science,Beijing 100050,China;Clinical effect of oxiracetam capsules in the children suffering from cerebral palsy[J];Chinese Journal of Neuromedicine;2007-04
3 FANG Bo,CAI Yun-hong,YUAN Peng,et al.(1.Department of Neurosurgery;2.Department of Neurology,Emergency Medical Center of Chongqing,Chongqing 400014,China);Clinical study of treating impediment of anamnesis and aptitude in the convalescent patients with severe head injury by oxiracetam[J];Chongqing Medical Journal;2005-11
4 ZHU Ji (Department of Neurosurgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China);Clinical study of oxiracetam for mild or medium brain injury[J];Acta Academiae Medicinae Militaris Tertiae;2006-10
5 YAO Ge,CHENG Jie,WANG Xiao-rong,LIU Zheng-guo Department of Neurology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;Clinical study of oxiracetam for treatment of Alzheimer's disease[J];Geriatrics & Health Care;2007-05
6 Hu Huanshun~1 Liu Zhenbao~2 (~1Department of Medicine,the Fourth People's Hospital,Huainan 232050,Anhui Province;~2Department of Neurology,Renji Hospital affiliated to Medical College,Shanghai Jiaotong University,Shanghai 200001,China);Treatment of Acute Cerebral Infarction with Oxiracetam Injection[J];Journal of Neurology and Neurorehabilitation;2008-01
7 XU Hong-hua.Affiliated Gulou Hospital of Nanjing University Medicine College,Nanjing,Jiangsu 210008,China;The comparison study of nicergolent and piracetam in treatment with vascular dementia.[J];Sichuan Medical Journal;2009-09
8 WANG Shu-zhen~(1*) CHI Zhao-fu~1 MA Lin~1 ZHANG Yong~2 DI Qing~3 HAN Zhao~4 YU Hao~5 HAN Ting~6 (1.Department of Neurology,Qilu Hospital of Shandong University,Ji-nan SHANDONG 250012,China:2.Department of Neurology,Shandong Provincial Hospital,Ji-nan SHANDONG 250021,China;3.Department of Brain Hospital of Nanjing Medical University,Nanjing JIANGSU 210029,China;4.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ZHEJIANG 325000,China;5.Department of Epidemiology and Biostatistics School of Public Health,Nanjing Medical University,Nanjing JIANGSU 210029,China;6.Shijiazhuang Pharmaceutical Group Ouyi Pharmaceutical Company,Shijiazhuang HEBEI 050051,China);A randomized double-blind controlled multicenter study with oxiracetam for injection in treatment of organic brain syndrome[J];Chinese Journal of New Drugs and Clinical Remedies;2007-04
9 Mu Haichuan,Liu Songqing,Ye Yaping (Department of Pharmacy,Southwest Hospital,Third Military Medical University,C hongqing,China 400038);Effect of Oxiracetam on Sodium and Potassium Channels in Hypothalamic Neurons of Rat[J];China Pharmaceuticals;2007-01
10 HUA Jin-bao (Zhejiang Province Anji the Third People's Hospital,313301,China);Clinical observation on oxiracetam's effects on rehsbitation of cognitive function in patients of hypertensive cerebral hemorrhage[J];Chinese Journal of Hospital Pharmacy;2008-14
【Secondary Citations】
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1 Liu Changxiao(Liu CX), Gu Yibao(Gu YB) and Li Quansheng(Li QS) (Tianjin Institute of Pharmaceutical Research, The State Pharmaceutical Administration of China, Tianjin 300193);PHARMACOKINETICS OF OXIRACETAM IN RATS AND MICE[J];ACTA PHARMACEUTICA SINICA;1999-02
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