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《China Modern Medicine》 2015-14
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Clinical effect observation of chemotherapy combined with Chinese herbs treatment after colorectal cancer surgery

ZHANG Zhao;HAN Zhen-guo;The First School of Clinical Medicine of Shanxi Medical University;  
Objective To observe the clinical effect of chemotherapy combined with Chinese herbs treatment after colorectal cancer surgery. Methods From Septemper 2012 to Septemper 2014,60 patients undergone colorectal cancer surgery were evenly divided into two groups,Chinese medicinal group(combination of FOLFOX6 chemotherapy regimen combined with Chinese herbs) and control group(only FOLFOX6 chemotherapy regimen).The curative effect of TCM syndrome,TCM symptom score,adverse reaction,serum carcino-embryonic antigen(CEA) and T cell subset between two groups was compared respectively. Results The total effective rate of TCM syndrome in Chinese medicinal group and control group was 70.00% and 26.67% respectively,and there was a statistical difference between two groups(P0.05).The TCM symptom score in two groups after treatment was(8.36±3.81) points and(15.40±4.90) points,and there was a statistical difference between two groups(P0.05).Comparision of adverse reaction between two groups:RBC,PLT level after treatment in Chinese medicinal group was obviously higher than that of control group respectively(P0.05);ALT,AST level after treatment in Chinese medicinal group was obviously lower than that of control group respectively(P0.05);there was a statistical difference of gastrointestinal toxicity and neurotoxicity response between two groups(P0.05).CD4+was obviously increased while CD8+was obviously decreased after treatment in Chinese medicinal group compared with control group(P0.05). Conclusion After colorectal cancer surgery,chemotherapy combined with Chinese herbs can effectively improve adverse reaction induded by chemotherapy(myelosuppression,gastrointestinal toxicity and neurotoxicity response) and immunity.
【CateGory Index】: R735.34
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