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《China Modern Medicine》 2015-23
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Optimization of the extractive factors of the Rhubarb total anthraquinones ingredients in Xin Jianwei chip tablet

LI Ping;LUO Jia-li;LI Yuan-feng;ZHENG Yan-chun;ZHANG Dong-ge;YANG Dong-li;ZHANG Rui-hua;Jingfukang Pharmaceutical Group Co., Ltd.in Hebei Province;Engineering Techonology Research Center of New Excipients of Traditional Chinese Medicine in Hebei Province;  
Objective To optimize the extraction factors of Rhubarb total anthraquinones ingredients in Xin Jianwei chip tablet, and to improve the quality standards to strengthen the quality control of products. Methods The extractive method was conducted a single-factor investigation,and the extraction temperature and time,and hydrolysis time were optimizated.The content of Rhubarb total anthraquinones ingredients in preparation used as an indicator of quality control was determined by HPLC method. Results The optimal extractive conditions of preparation were determined as follows:reflux extraction of methanol at 75℃ for 1.5 h,then,8% hydrochloric acid for acidification,and continued to extract for 2.0 h,at this time,the extraction rate of active components was the highest,and total anthraquinones ingredients were most stable. Conclusion This method is stable and feasible,and it can be used as quality control method of the preparation.
【Fund】: 河北省科学技术成果(冀科成转鉴字[2012]第9-732号)
【CateGory Index】: R286.0
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