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《China Modern Medicine》 2017-14
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Efficacy and safety analysis of Clozapine combined with Amisulpride in the treatment of refractory schizophrenia

ZENG Hui-ying;SONG Dan-xing;WU Zhong-jian;Department of Psychiatry,Chronic Disease Prevention and Control Station of Taishan City in Guangdong Province;  
Objective To explore the efficacy and safety of Clozapine combined with Amisulpride in the treatment of refractory schizophrenia.Methods 80 patients with refractory schizophrenia admitted in our hospital from June 2015 to June 2016 were selected and divided into the control group and the observation group according to the random number table method,40 cases in each group.The control group was treated with Clozapine,the observation group was treated with Clozapine combined with Amisulpride.The PANSS and TESS were used to evaluate the clinical efficacy and adverse drug reactions of the two groups after 12 weeks of the treatment.Results The total effective rate after treatment of the observation group was 80.0%,which was significantly higher than that of the control group(62.5%),with significant difference(P0.05).The total score of PANSS,the negative and positive symptom scores after treatment in the observation group was significantly lower than that in the control group,with significant difference(P0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P0.05).Conclusion The curative effect of Clozapine combined with Amisulpride in the treatment of refractory schizophrenia is significant,it is safe with less adverse reaction.
【CateGory Index】: R749.3
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