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《Chinese Journal of Practical Surgery》 2008-08
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Percutaneous radiofrequency ablation and surgical resection for small hepatocellular carcinoma:a comparative study

PENG Zhen-wei,XU Li,CHEN Min-shan,et al.Derpartment of Hepatobiliary Surgery,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China  
Objective To compare the effectiveness of percutaneous radiofrequency ablation (PRFA) and surgical resection as an initial treatment for patients with small hepatocellular carcinoma (HCC).Methods Between November 1999 and June 2004,434 patients with a solitary HCC (diameter less than 5cm) and well-preserved liver function (Child-pugh class A ) received PRFA or surgical resection (SR) in Sun Yat-sen University Cancer Center.Among them,183 patients received SR and 251 patients received PRFA.Results The overall 1-year,3-year and 5-year survival rates for SR group were 91.18%,70.18%,55.51% respectively,and for PRFA group were 91.92%,74.41%,58.22% respectively.In patients with tumor diameter ≤3cm,the overall 1-year,3-year and 5-year survival rates for SR group were 95.87%,73.69%,62.45% respectively,and for PRFA group were 95.46%,80.15%,72.79% respectively.In patients with tumor diameter from 3.0m to 5.0cm, the overall 1-year,3-year and 5-year survival rates for SR group were 88.07%,67.63%,51.18% respectively,and for PRFA group were 80.16%,60.63%,32.34% respectively.Survival of patients treated with PRFA were dependent on tumor size and serum bilirubin.Conclusion PRFA is as effective as surgical resection in the group of solitary and small HCC.PRFA can be used instead of surgical resection in proper situations.
【Fund】: 广东省科委社会攻关基金资助项目(2006B36002008)
【CateGory Index】: R735.7
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