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《Chinese Journal of Health Statistics》 2007-02
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The Stepwise Discriminant Analysis of Random Forests Used in Gene Expression Data

Wu Xiaoyan,Yan Xiaoguang,Li Kang.Department of Medical Statistics,Harbin Medical University (150001),Harbin  
ObjectiveWe promote a new arithmetic of random forests,which selects variables automatically during the model formation and establishes the optimal discriminant model.MethodsThe arithmetic chooses variables based on the values of variable importance and the stepwise iteration.The method is applied to real gene datasets and we validate its effect using R language via simulated tests.ResultsThe optimal discriminant model performs well in real gene expression data with small number of genes being selected.The simulated tests show that the higher the value of ROC area,the better results of discrimination Random Forests achieve,and the differential variables still remain in the model to promote the effect of classification.ConclusionThe stepwise discriminant analysis of Random Forests can be effectively applied to the research of gene selection and classification.Meanwhile,we should pay close attention to the impact produced by random fluctuation on the results.
【Fund】: 国家自然科学基金资助(30371253);; 黑龙江省重点项目(GB04C30202)
【CateGory Index】: R195
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【References】
Chinese Journal Full-text Database 1 Hits
1 WANG Jing XIA Jie-lai YE Dong-qing (1.Department of Epidemiology and Health Statistics,Anhui Medical University,Hefei,230032, China; 2.Department of Prevental Medicine,the Forth Military Medical University,Xi'an,710000,China);Improvement of Discriminant Analysis in the Medical Area[J];Application of Statistics and Management;2008-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CAI Jian-rong et al(School of Food & Biological Engineering,Jiangsu University,Zhenjiang,Jiangsu 212013);Application of Near Infrared Reflectance Spectroscopy in Identification of Different Classified Tea[J];Journal of Anhui Agricultural Sciences;2007-14
2 WANG Yong 1,2 ,CHEN Shu xia 1,XUE Yin 1,DONG Jie 1,JIN Qi 1,HOU Yun de 1(1.State Key Laboratory for Molecular Virology and Genetic Engineering,Institute of Viral Disease Control and Prevention,China CDC,Beijing 100052,Ch;Sequencing and Analysis of the HA1 Gene of Human Influenza Virus(H_3N_2) in China from 1968~2000[J];Chinese Journal of Virology;2002-02
3 DONG Li-bo,ZHANG Ye,WEN Le-ying,ZHAO Xiang,HUANG Wei-juan,LAN Yu,GUO Jun-feng,LI Zi,WANG Min,DONG Jie,GUO Yuan-ji,SHU Yue-long(Chinese Influenza Center,National Institute for Viral Disease Control and Prevention.,Chinese Center for Disease Control and Prevention,State Key Laboratory for Infectious Disease Prevention and Control,Beijing 100052,China);Study on the Correlation of Human Influenza A/H3N2 Hemagglutinin Gene Variation and the Epidemic from 1995 to 2005 in China[J];Chinese Journal of Virology;2007-05
4 DONG Yuanfang1,LI Jun2 (1. School of Economics and Management,Changchun University of Science and Technology,Changchun 130022; 2. School of Sciences,Changchun University of Science and Technology,Changchun 130022);Theoretical Analysis and Application of Boosting Algorithm[J];Journal of Changchun University of Science and Technology(Natural Science Edition);2009-02
5 Li Zheqian1 Liu Shupeng1 Yan Zhuangzhi1 Huang Hai2(1.Institute of Biomedical Engineering School of Communication and Information Engineering,Shanghai University,Shanghai 200072;2.College of Life,Shanghai University,Shanghai 200072);Predicting protein-protein interactions with support vector machines[J];Electronic Measurement Technology;2008-05
6 Xu Yongqun 1,3 , Huang Hao 1, Zhou Qun 1, Zhou Hongtao 2, Hu Shilin\+2, Sun Suqin *1 1(Department of Chemistry, Tsinghua University,Beijing 100084) 2(Chinese Academy of Traditional Chinese Medicine, Beijing 100700) 3(Department of Chemistry, Huanggang Teachers College, Huanggang 438000;The Application of Fingerprint Infrared Spectra and Clustering Analysis in the Discrimination of Geographical Origin of Paeonia lactiflora Pall[J];Chinese Journal of Analytical Chemistry;2003-01
7 Zhu Er-Yi, Lin Yan, Zhuang Zan-Yong (Department of Chemistry and the Key Laboratory of Analytical Science of the Ministry of Education, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005);Partial Least Squares Variable Selection Method and Its Application in Drug Source Analysis[J];Chinese Journal of Analytical Chemistry;2007-07
8 Lin Yan-Ping1,2,Si Duan-Yun2,Liu Chang-Xiao2 1(Department of Pharmaceutical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072) 2(Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193);Advances of Liquid Chromatography/Mass Spectrometry Combined with Chemometric Approaches Applied to Metabonomics[J];Chinese Journal of Analytical Chemistry;2007-10
9 ZHU Xiang-Rong1,2, LI Na2,SHI Xin-Yuan2,QIAO Yan-Jiang2,ZHANG Zhuo-Yong1 1(Department of Chemistry,Capital Normal University,Beijing 100037)2(School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102);Study on Chinese Medicinal Qingkailing Injection Intermediate by Least Squares Support Vector Machines and Ultraviolet Spectrometry[J];Chinese Journal of Analytical Chemistry;2008-06
10 YAO Wei-Feng1,2,HU Yu-Zhu2,MOU Ling-Li3,YU Bo-Yang31(Department of Pharmaceutical Analysis,Nanjing University of Chinese Medicine,Nanjing 210046)2(Key laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,Department of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009)3(Key Laboratory of Modern Chinese Medicines,Ministry of Education,Department of Chinese Prescription,China Pharmaceutical University,Nanjing 210009);Prediction of Total Ginkgo Biloba Leaves Antioxidant Capacity from Chromatographic Fingerprints by Least Squares-Support Vector Machines[J];Chinese Journal of Analytical Chemistry;2009-03
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 WANG Wen,YANG Tu-bao,ZHANG Zhe,et al.(School of Public Health,Central South University,Changsha 410078,Hunan);Research Summarization of Comprehensive Evaluation on Student's Physical Fitness[J];Practical Preventive Medicine;2010-01
2 ZENG Gao1,JIAO Feng1,SONG Xiuhui2,et al. 1. Department of Neurosurgery,People Hospital,Peking University,Beijing,100044,China;2. Department of Neurosurgery,People's Hospital of Jimo,Jimo 266200,China;Establishment of semi-quantitative mathematical model of intracranial pressure using nonparametric stepwise discriminant analysis[J];Chinese Journal of Minimally Invasive Neurosurgery;2009-06
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