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《Food and Nutrition in China》 2015-02
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Anti-alcoholism Effects of Honey on Acute Alcoholism Rat

LIANG Lu-lu;WANG Ying-jiao;JIN Xiao-bao;School of Basic Courses/Guangdong Pharmaceutical University/Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances;  
Objective!!!"To explore anti-alcoholism effects of honey on acute alcoholism rats and its effects on alcohol metabolizing enzyme. !!!!"Method!!"Acute alcoholism rat models were set up by single gavage using 75% anhydrous ethanol with the concentration of 10 m L / kg.Compard with hangover drink Dingjiu liquid( a commercial product),high,moderate and low concentration of honey were given to above formed intoxicated rats to investigate its anti-alcoholism effects. The alcohol concentration in blood serum,the activity of ADH and ALDH in liver and stomach tissue of acute alcoholism rats were used as indexes. !!!!"Result!!"Compared with model control group,the serum ethanol concentrations in low and moderate concentration of honey groups were significantly lower( P 0. 05),while it was very significantly lower in high group( P 0. 01). The activity of ADH in liver and ALDH in stomach tissue of moderate and high concentration of honey groups were very significantly increased( P 0. 01),and the activity of ADH in stomach and ALDH in liver tissue of all honey groups were significantly increased( P 0. 05 or P 0. 01). !!!"Conclusion!!!"Honey could effectively alleviate hangover and decreased alcohol content in blood serum by increasing the activity of ADH and ALDH in liver and stomach tissue of acute alcoholism rats.
【CateGory Index】: R151;S896.1
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