Study of Platelet Membrane Glucoprotein CD62p,CD63 Expression and Platelet Four Parameters in Type 2 Diabetic Patients With Vascular Disease
Mao Dayong, Zhou Youli, Li Dekui. Department of Clinical Laboratories, Shiyan City Taihe Hospital,Shiyan (442000),Hubei
Objective:To investigate the changes of platelet membrane glucoprotein CD62 p, C D63 expression and four parameters of platelet in type 2 diabetic patients with vascular disease. Methods: Platelet membrane glucoprotein CD62p, CD63 expression and platelet four parameters (platelet count (PLT), mean platel et volume (MPV), plateletcrit (PC T) and platelet distribution width (PDW)) were analyzed by fLow cytometric immun ofluorescence (FCM) and automatic blood analyzer in 42 d iabetic patients wi th vascular disease, and compared with those of 50 diabetic patients without v ascular disease, and 46 normal controls. Results: The positive rates of CD62p, CD63 and the quantity of MPV in type 2 di abetic patients with vascular disease were (11 64±3 79)%, (15 73±4 22)% and (1 1 85±2 31)fl, significantly higher than those in normal controls (2 27±2 11)% ,p 0 001, (6 83±2 85)%,p0 001,(10 72±1 63)fl,p0 01. The patients with va scular disease were significantly higher than those of type 2 diabetic patients without vascular disease (10 01±3 65)%, p0 05,(14 02±3 78)%,p 0 05. Conclusion: The measurements of the platelet membrane glucoprotein CD62p, C D63 expression and mean platelet volume have very important value for indicating the platelet activation that contributs to the development of vascular disease in p atients with type 2 diabetes mellitus.
【CateGory Index】： R587.1