Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Circulation Journal》 2019-01
Add to Favorite Get Latest Update

Effects of Enalapril Maleate and Folic Acid Tablets on Contrast-induced Nephropathy in Diabetic Rats and Related Mechanism

HOU Jiantong;YAN Gaoliang;WANG Dong;QIAO Yong;ZHU Boqian;LIU Bo;LUO Erfei;TANG Chengchun;Department of Cardiology, Zhongda Hospital of Southeast University School;  
Objectives: To investigate the effects of enalapril maleate and folic acid tablets(EF) on contrast-induced nephropathy(CIN) in diabetic rats and explore the related mechanisms.Methods: 32 male SD rats were randomly divided into four groups: control group(CTL), control+EF group, CIN group, CIN+EF group. The early diabetic model was established by intraperitoneal injection of streptozotocin(60 mg/kg) in CIN group and CIN+EF group. Rats in control+EF and CIN+ EF group were treated with enalapril maleate and folic acid tablets [30 mg/2.4 mg/(kg·d)] for 7 consecutive days prior CIN induction, rats in CTL and CIN groups were treated with same amount of saline for 7 days. CIN was induced by sequential tail vein administration of indomethacin(10 mg/kg), L-NAME(10 mg/kg), and loperamide(10 ml/kg). Rats were sacrificed at 2 days after induction of CIN and the biochemical indexes, pathological changes, apoptosis and ILK protein expression in serum and kidney were measured. Results: Serum creatinine(Scr), blood urea nitrogen(BUN), homocysteine(Hcy), ILK, Angiotensin Ⅱ(Ang Ⅱ)level,pathological damage score, apoptosis index and ILK protein expression in CIN group were significantly increased compared with those of the control group(P0.05). Scr, BUN,Hcy, ILK, AngII level,pathological damage score, apoptosis index and ILK protein expression were significantly decreased in CIN+EF group compared with those of the CIN group(P0.05).Conclusions: The EF may play a protective role against contrast-induced nephropathy in diabetic rats, and its mechanism may be mediated through the reduction of AngII、ILK, Hcy levels.
【Fund】: 国家自然科学基金(81600227)
【CateGory Index】: R587.2;R692.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 YE Piao;TAN Ning;LIU Yong;LIU Yuan-hui;HE Yi-ting;RAN Peng;LI Hua-long;JIANG Lei;Department of Cardiology,Guangdong General Hospital;;Impact for Different Dose of Atorvastatin on Contrast-induced Nephropathy in Patients With High Level of hs-CRP After Percutaneous Coronary Intervention[J];中国循环杂志;2014-04
2 GU Yun-juan*, CHEN Xiang-mei, CUI Shi-wei,SUN Xue-feng,LI Zhi-hui, SHI Suo-zhu, L Yang, CAI Guang-yan. *Department of Nephrology, Kidney Center and Key Lab of PLA, General Hospital of PLA, Beijing 100853, China Corresponding author:CHEN Xiang-mei, Email: xmchen@public.bta.net.cn;Expression and role of integrin-linking kinase in renal tubulointerstitial lesion of aging rats[J];中华内科杂志;2005-10
Chinese Journal Full-text Database 10 Hits
1 PENG Jun-fu;CHU Jun;SUN Ming-yu;HAN Yong-sheng;CHEN Chen;Department of Cardiology, Anhui Medical University Affiliated Provincial Hospital;;Effect of Vitamin E for Preventing the Contrast Induced-nephropathy in Patients With Coronary Artery Disease After Percutaneous Coronary Intervention[J];中国循环杂志;2015-12
2 LIU Zhe-bo;XIA Hao;LI Jing;Department of Cardiology, People's Hospital of Wuhan University;;Influencing Factors of Contrast- induced Nephropathy in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention[J];实用心脑肺血管病杂志;2015-08
3 YANG Xu;HUANG Xiao-qing;HUA Lu;SUN Hui;ZHANG Hai-hua;WANG Lin-ping;ZHANG Wei;WANG Li;PANG Hui-min;ZHANG Yun;DANG Ai-min;Center of Special Medical Care, Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC;;Analysis of Allergic Adverse Reaction Caused by Non-ionic Iodinated Contrast Media in 52 Patients With Coronary Angiography[J];中国循环杂志;2015-08
4 XU Dan;WANG Jing;LIAO Hua-wei;LIU Xiao-hui;FENG Jiang-chao;Department of Nephrology,Affiliated Hospital of North Sichuan Medical College;Gansu Traditional Chinese Medicine College Jiuquan Vocational and Technical College;;Influences of application of different doses of atorvastatin before PCI on acute kidney injury induced by contrast agent[J];中国医学前沿杂志(电子版);2015-07
5 Sun Yunpeng;Qiqihaer Municipal First Hospital;;Clinical Effect of Atorvastatin Combined with Valsartan in Treatment of Permanent Atrial Fibrillation and Its Influence on Plasma hs-CRP and NT-proBNP Levels in 50 Cases[J];中国药业;2015-13
6 YAN Li-juan;Computed Tomography Room, 208th Hospital of People′s Liberation Army;;Application effect of contrast agent by heating on CT enhancement scan[J];中国当代医药;2015-18
7 CHEN Yuyi;Department of Cardiovasology,Dongguan People's Hospital,Guangdong Province;;Study on effect of intensive Atorvastatin for intervention of contrast induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome[J];中国医药导报;2015-18
8 HE Hai-yan;LI Wen-hua;WANG Lin;YU Ya-ren;CHEN Jing;Department of Cardiology,Affiliated Hospital of Xuzhou Medical College;;Effect of L-carnitine on Preventing Contrast-induced Nephropathy in Patients With Coronary Artery Disease Combining Diabetes Mellitus After Percutaneous Coronary Intervention[J];中国循环杂志;2015-04
9 ZHENG Jing;PAN Xian-feng;Department of Internal Medicine,Kaixian People′s Hospital;;Role of NGAL and KIM-1 on diagnostic effects and hydration therapy in patients with contrast-induced nephropathy[J];西部医学;2015-02
10 ZHAO Jing;WANG Yingchao;ZHAO Zongjiang;Beijing University of Chinese Medicine;;Tangshenping Intervene Podocytes Epithelial-mesenchymal Transition Induced with High Glucose + LPS by TGF-β_1-Smad2/3-ILK Signal Transduction Pathway[J];中国中西医结合肾病杂志;2014-05
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 YU Deng-ji1,SU Jin-zi1,CHEN Guang-ling2,CAI Wen-qin1,JIN Xue-qing1,CHAI Da-jun1(1.Department of Cardiology,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;2.Department of Cardiology,Affiliated Mindong Hospital of Fujian Medical University,Fuan 355000,China);Effect of different doses of Atorvastatin in contrast-induced nephropathy[J];中国介入影像与治疗学;2010-05
2 MA Yu-liang,WANG Wei-min,LIU Jian,LU Ming-yu,LI Qi,LIU Chuan-fen. Department of Cardiology,Peking University People's Hospital,Beijing(100044),China;Relationship Between High Sensitivity C-Reactive Protein and Contrast Induced Nephropathy[J];中国循环杂志;2009-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved