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《Chinese Circulation Journal》 2019-01
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Effects of Enalapril Maleate and Folic Acid Tablets on Contrast-induced Nephropathy in Diabetic Rats and Related Mechanism

HOU Jiantong;YAN Gaoliang;WANG Dong;QIAO Yong;ZHU Boqian;LIU Bo;LUO Erfei;TANG Chengchun;Department of Cardiology, Zhongda Hospital of Southeast University School;  
Objectives: To investigate the effects of enalapril maleate and folic acid tablets(EF) on contrast-induced nephropathy(CIN) in diabetic rats and explore the related mechanisms.Methods: 32 male SD rats were randomly divided into four groups: control group(CTL), control+EF group, CIN group, CIN+EF group. The early diabetic model was established by intraperitoneal injection of streptozotocin(60 mg/kg) in CIN group and CIN+EF group. Rats in control+EF and CIN+ EF group were treated with enalapril maleate and folic acid tablets [30 mg/2.4 mg/(kg·d)] for 7 consecutive days prior CIN induction, rats in CTL and CIN groups were treated with same amount of saline for 7 days. CIN was induced by sequential tail vein administration of indomethacin(10 mg/kg), L-NAME(10 mg/kg), and loperamide(10 ml/kg). Rats were sacrificed at 2 days after induction of CIN and the biochemical indexes, pathological changes, apoptosis and ILK protein expression in serum and kidney were measured. Results: Serum creatinine(Scr), blood urea nitrogen(BUN), homocysteine(Hcy), ILK, Angiotensin Ⅱ(Ang Ⅱ)level,pathological damage score, apoptosis index and ILK protein expression in CIN group were significantly increased compared with those of the control group(P0.05). Scr, BUN,Hcy, ILK, AngII level,pathological damage score, apoptosis index and ILK protein expression were significantly decreased in CIN+EF group compared with those of the CIN group(P0.05).Conclusions: The EF may play a protective role against contrast-induced nephropathy in diabetic rats, and its mechanism may be mediated through the reduction of AngII、ILK, Hcy levels.
【Fund】: 国家自然科学基金(81600227)
【CateGory Index】: R587.2;R692.9
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【Citations】
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【Co-citations】
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1 PENG Jun-fu;CHU Jun;SUN Ming-yu;HAN Yong-sheng;CHEN Chen;Department of Cardiology, Anhui Medical University Affiliated Provincial Hospital;;Effect of Vitamin E for Preventing the Contrast Induced-nephropathy in Patients With Coronary Artery Disease After Percutaneous Coronary Intervention[J];中国循环杂志;2015-12
2 LIU Zhe-bo;XIA Hao;LI Jing;Department of Cardiology, People's Hospital of Wuhan University;;Influencing Factors of Contrast- induced Nephropathy in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention[J];实用心脑肺血管病杂志;2015-08
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