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《Chinese Journal of Preventive Veterinary Medicine》 2008-05
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Effect of endotoxin on the expression of Bcl-2 and the apoptosis of the hepatocyte

WENG Yin-biao1,2,GAO Hong1,YANG Jian-fa1,ZHAO Ru1,GAO Li-bo1,PENG Jie1,AO Ping-xing1 (1. Department of Science and Technology of Animal,Yunnan Agricultural University,Kunming 650201,China; 2. Guangzhou Institute of Pharmaceutical Industry,Guangzhou 510240,China)  
To study on the effect of endotoxin on the apoptosis and the expression of Bcl-2 in the liver. Forty-eight Wistar rats were randomly divided into two groups: the normal controls group (groupⅠ) and ET treatment group (groupⅡ). Aftert three,four,eight and twelve hours liver samples were taken. Compared with control groups,the ET groups hepatocyte percentage of apoptosis significantly increased (P0.01). And the immunohistochemical examination with Bcl-2 of ET groups exhibited that the Bcl-2 decrease markedly (P0.01) compared with the control groups. These results indicated that ET could stimulate apoptosis of hepatocyte and up-regulate the Bcl-2 gene expression in the liver. And the up-regulate the Bcl-2 gene can result in the reducing the apoptosis of hepatocyte.
【Fund】: 国家自然科学基金资助项目(30560113)
【CateGory Index】: R363
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