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《Journal of China Pediatric Blood and Cancer》 2006-03
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The clinical significance of platelet parameter changes in idiopathic thrombocytopenic purpura

Pu Xiuhong, Li Qian, Li Jin, Guo Xiaoqing, Qiu Meng, An Tao. Department of pediatrics, 309~ th Clinical Division, General Hospital of the Peple's Liberation Army, Beijing 100091, China  
Objective To explore the clinical significance of platelet parameter changes in idiopathic thrombocytopenic purpura (ITP).Methods The platelet total (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) and platelet larger cell ratio (P-LCR) were detected in 67 cases of idiopathic thrombocytopenic purpura (ITP) before and after treatment. It was compared with 50 cases of normal children.Results (1) Before the treatment PLT in ITP was obviously decreased than that of the normal children (P0.001). MPV, PDW and P-LCR were obviously increased than those of the normal children (P0.001). After the treatment PLT was significantly increased, MPV, PDW and P-LCR were reduced significantly (P0.001). (2) The abnormalities of the platelet parameter became significant with the procession of ITP stages. But MPV was reduced in extreme severe form. (3) MPV was negatively correlated with PLT (P0.001).MPV positively correlated with PDW, MPV positively correlated with P-LCR, PDW positively correlated with P-LCR (P0.05).Conclusion Dynamical observation of the platelet parameter helps for the differential diagnosis, telling the degrees of the states of the patients and observing the effectiveness of therapy of ITP.
【CateGory Index】: R725.5
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