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《China Pharmacy》 2005-01
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Preparation and Quality Control of Dibing Gel

HONG Qing,YUAN Xi,ZHU Shanlan(Dept.of Pharmacy,The First Affiliated Hospital of Fujian Medical University,Fuzhou350005,China) CHENG Qingwei(Fuzhou Institute for Drug Control,Fuzhou350001,China)  
OBJECTIVE:To prepare Dibing gel and establish its quality control method.METHODS:The0.5%Carbopol940was taken as the base of gel.The content of dexamethasone acetate was determined by HPLC.The stability and the skin irritation test were studied,too.RESULTS:The calibration curve of dexamethasone acetate was linear in the range of20~120μg/ml.The average recovery of dexamethasone acetate was101.1%,RSD=0.92%.The preparation was stable and had no irritation to skin.CONCLUSION:The gel was resonable in formulation,convenient in preparation technique,and simple and accurate in method of quality control.
【CateGory Index】: R943
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