Study on the Distribution of Gatifloxacin in Ocular Tissues and Its Pharmacokineties in Rabbit
ZHOU Yuanda,HE Haixia(Clinical Pharmacology Laboratory, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016,China)HAN Min,ZHE Xuejun,WU Yan(Dept. of Pharmacy, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016,China)
OBJECTIVE: To study distribution and pharmacokinetics of gatifloxacin in ocular tissues of rabbit after ocular instillation.METHODS: The drug concentrations in ocular tissues were determined by HPLC after topical ocular instillation in rabbits;the pharmacokinetics parameters were figured out by 3p97 process. RESULTS: Results showed that the peak concentration of gatifloxacin in lacrimal fluid, cornea, aqueous humor, iris-ciliary body, lens and vitreous body 0.125h～1.0h after topical instillation were (1 115.75±151.04)μg/ml,(17.90±1.39)μg/g,(2.26±0.18)μg/ml,(9.12±0.33)μg/g,(1.07±0.13)μg/g and (0.77±0.04)μg/g respectively;t1/2β in various tissues were(2.14±0.33),(2.82±0.54),(3.33±0.43),(3.88±1.21),(3.89±1.43) and (3.14±0.43)h respectively;AUC(0→t) in various tissues were(541.77±69.73)(μg·h)/ml,51.31±3.04)(μg·h)/g,(6.55±0.45)(μg·h)/ml,(51.99±25.66)(μg·h)/g,(4.19±0.41)(μg·h)/g and (3.25±0.13)(μg·h)/g respectively.CONCLUSION:Gatifloxacin has a good permeability and high concentration in various intraocular tissues of rabbit after ocular instillation.
【CateGory Index】： R96