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《China Pharmacy》 2005-21
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Comparative Study on in Vivo Pharmacokinetics of Gatifloxacin between Normal Canis Familiaris and Hepatic Injury Model

DENG Lidong, DENG Hang, DENG Jungang, FU Xiang (Dept. of Pharmacy, The Affiliated Hospital of Guilin Medical College, Guilin 541001, China) JANG Xuehua (West-China College of Pharmacy, Sichuan University, Chengdu 610041, China)  
OBJECTIVE: To compare the in vivo pharmacokinetics of gatifloxacin between normal canis familiaris and hepatic injury model group. METHODS: Hepatic injury model was established by injecting canis familiaris intraperitoneally with carbon tetrachloride solution. Samples were taken respectively following the specified time schedule after administration with gatifloxacin. Blood concentrations of which at different time were determined by HPLC. The pharmacokinetic parameters were calculated with 3p87 program software and the results were compared with those of the normal group. RESULTS: The main pharmacokinetic parameters of gatifloxacin in the normal group and the hepatic injury model group all assumed one compartment model. The main pharmacokinetic parameters of gatifloxacin of the normal group and the model groups were respectively as follows: tmax were (2.35±0.75) h and(1.06±0.32) h, t1/2ke were (8.38±2.03) h (8.91±1.21) h, Cmax were (2.29±0.11)mg/L and (2.63±0.07)mg/L; AUC were (33.82±6.78)(μg·h)/ml and (36.80±4.67)(μg·h)/ml. No significant difference was noted between the two groups from the t - test(P 0.05) . CONCLUSION: Gatifloxacin has no significant influence on pharmacokinetics of the hepatic injury model group as compared with the normal group.
【Fund】: 广西壮族自治区自然科学基金资助项目(0249016)
【CateGory Index】: R96
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