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《China Pharmacy》 2006-11
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Preparation and Per Cutem Permeability Test of Ketoprofen Poultice

CHE Xiaoxia,XI Zhixia(The Second Hospital of Xi'an Jiaotong University,Xi'an710004,China) YU Limin(Shenyang Pharmaceutical University,Shenyang110016,China)  
OBJECTIVE:To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors.METHODS:Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell.RESULTS:The optimal poultice was acquired with adhesive stress at40N and steady permeation flux at9.72μg/(cm 2 ·h).CONCLUSION:The established preparation technique of poultice is stable and feasible,and its leading influencing factors are adhesive stress and transdermal effects.
【CateGory Index】: TQ463.2
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