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《China Pharmacy》 2007-25
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Preparation and Dissolution Rate of Gliquidone Solid Dispersion

PAN Zhenhua, XIANG Bai, FANG Yu, DUN Jiening( College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China) LIU Huanlong( Dept. of Pharmacy, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China)  
OBJECTIVE: To prepare gliquidone solid dispersion and to investigate its dissolution rate. METHODS: The gliquidone solid dispersion was prepared by dissolvent- fusion method and dissolvent method with PEG- 6000( PEG) and PVP K30( PVP) as carriers. RESULTS: The results of in vitro dissolubility test showed that the higher the carrier ratio, the faster the drug dissolution. The in vitro dissolubility of solid dispersions was faster with PVP than with PEG as carrier. The dissolution rate of the gliquidone- PVP ( 1∶ 7) solid dispersion reached as high as above 70% in 10 minutes, which was superior to that of its bulk drug. CONCLUSION: The gliquidone solid dispersion has been prepared successfully.
【CateGory Index】: TQ463
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