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《China Pharmacy》 2008-18
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Preparation and Stability of Acanthopanax Senticosi Soft Capsule

WEI Zhao-fu(Henan Puyang Municipal People's Hospital, Puyang 457000, China)YAN Xi-qing,JIA Qiang (Research Institute of Tinghua University in Shenzhen, Shenzhen 518057, China)YAN Xi-qing(Traditional Chinese Medicine & National Product Research Center, Shenzhen 518057, China)JIANG Qing-feng(Dept. of Pharmacy, South Hospital, Southern Medical University, Guangzhou 510505, China)ZHANG Wei(China Pharmacy Publishing House, Chongqing 400042, China)  
OBJECTIVE: To prepare Acanthopanax senticosi soft capsule and investigate their accelerated and long-term stability. METHODS:Acanthopanax senticosi was extracted by alcohol to be prepared into extract, then into suspension by adding suitable adjuvant and optimizing the dosage of the suspending agent, and the suspension was encapsulated to prepare soft capsule with the content determined by HPLC. The accelerated and long-term experiments of the capsule were carried out. RESULTS: Reddish vernicose soft capsule with good stability were obtained by encapsulating Acanthopanax senticosi suspension with suitable substance. The Acanthopanax senticosi soft capsule showed high stability in long-term and accelerated experiments, with redispersibility, disintegration and content uniformity all coincided with the China Pharmacopeia (2005 Edition). CONCLUSION:Acanthopanax senticosi soft capsule are of permanent stability, and this result serves as a theoretic basis for the industrial production of Acanthopanax senticosi soft capsule.
【CateGory Index】: TQ461
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