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《China Pharmacy》 2009-24
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Effects of Alcohol Extracts of Averrhoa carambola on Blood Glucose Level and Antioxidant Activity in Streptozocin-induced Diabetic Model Mice

HUANG Gui-hong,HE Min,HUANG Ren-bin(Pharmaceutical School,Guangxi Medical University,Nanning 530021,China)HUANG Gui-hong(The Affiliated Hospital of Guilin Medical College,Guilin 541001,China)MA Jie-jin(Guangxi Health Management Cadre College,Nanning 530021,China)  
OBJECTIVE: To study the effects of alcohol extracts of Averrhoa carambola(ACLRE) on blood glucose level and antioxidant activity in STZ-induced diabetic model mice.METHODS: Diabetic model was induced in mice by intraperitoneal injection of streptozotocin(STZ),and the model mice were divided into 5 different groups: normal group,model group,glibenclamide group,high-dose group and low dose group of ACLRE.The mice were administered with corresponding drugs for 14 days.The levels of fasting blood glucose(FBG) were determined at 0,7 and 14 days.The experimental mice were sacrificed on day 14 for the determination of the activity of SOD and concentration of MDA in blood serum and liver.RESULTS: As compared with model group,the FBG in mice treated with either high dose or low dose ACLRE were down-regulated significantly(P0.01),and in mice treated by high dose ACLRE,the activity of SOD in blood serum and liver was higher(P0.01) while concentration of MDA was lower(P0.01).CONCLUSION:The ACLRE has remarkable hypoglycemic effect on diabetic model mice.It can improve the antioxidant activity by enhancing the activity of SOD and decrease the concentration of MDA in mice and it is a potential hypoglycemic agent for treatment of diabetes and its complication.
【Fund】: 广西科学基金项目(桂科自0832013Z)
【CateGory Index】: R285
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