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《China Pharmacy》 2010-21
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Effect of Xylitol on Bone Histomorphology of Diabetic Rats

ZHENG Jin-liang,YU De-min,SUN Li-rong(Metabolic Disease Hospital,Tianjin Medical University,Key Lab of Hormones and Development,Ministry of Health,Tianjin 300070,China) GAO Xiu-mei(No.254 Hospital of PLA,Tianjin 300070,China)  
OBJECTIVE: To evaluate the effects of xylitol (Xy) on bone histomorphology of diabetic mellitus (DM) rats.METHODS: 48 male Wistar rats were randomly divided into diabetic control (DC) group,DM+10%Xy group,DM+20%Xy group,normal control (NC) group,NC+10%Xy group,NC+20%Xy group.Diabetic models of former three groups were induced by alloxan.All groups were given other drugs for 12 weeks and sacrificed.Blood samples and bone samples were collected to determine the level of calcium,phosphorus,ALP,BGP and bone histomorphormetric index,such as mean trabecular plate density (MTPD),mean trabecular plate space (MTPS),distance between double tetracycline labeling (DDL),bone mineral apposition rate (MiAR) and Svf.RESULTS: The level of blood glucose in DM+20%Xy group and DM+10%Xy group were significantly lower than in DC group;The level of ALP and BGP in serum of DC group were lower than in NC group;the level of MTPD in DM+20%Xy group was higher than in DC group and DM+10%Xy group (P0.05);the level of MTPS in DC group was higher than in NC group;the level of DDL,MiAR and Svf in DM+20%Xy group and NC group were higher than DC group (P0.01).CONCLUSION: These results show the abnormality of bone histomorphometric parameters in DM rats.Xylitol can improve bone histomorphometric properties and may prevent osteoporotic changes in diabetic rats.
【Fund】: 天津市卫生局科技基金项目(03KZ33)
【CateGory Index】: R587.1
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