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《China Pharmacy》 2010-21
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Effect of Xylitol on Bone Histomorphology of Diabetic Rats

ZHENG Jin-liang,YU De-min,SUN Li-rong(Metabolic Disease Hospital,Tianjin Medical University,Key Lab of Hormones and Development,Ministry of Health,Tianjin 300070,China) GAO Xiu-mei(No.254 Hospital of PLA,Tianjin 300070,China)  
OBJECTIVE: To evaluate the effects of xylitol (Xy) on bone histomorphology of diabetic mellitus (DM) rats.METHODS: 48 male Wistar rats were randomly divided into diabetic control (DC) group,DM+10%Xy group,DM+20%Xy group,normal control (NC) group,NC+10%Xy group,NC+20%Xy group.Diabetic models of former three groups were induced by alloxan.All groups were given other drugs for 12 weeks and sacrificed.Blood samples and bone samples were collected to determine the level of calcium,phosphorus,ALP,BGP and bone histomorphormetric index,such as mean trabecular plate density (MTPD),mean trabecular plate space (MTPS),distance between double tetracycline labeling (DDL),bone mineral apposition rate (MiAR) and Svf.RESULTS: The level of blood glucose in DM+20%Xy group and DM+10%Xy group were significantly lower than in DC group;The level of ALP and BGP in serum of DC group were lower than in NC group;the level of MTPD in DM+20%Xy group was higher than in DC group and DM+10%Xy group (P0.05);the level of MTPS in DC group was higher than in NC group;the level of DDL,MiAR and Svf in DM+20%Xy group and NC group were higher than DC group (P0.01).CONCLUSION: These results show the abnormality of bone histomorphometric parameters in DM rats.Xylitol can improve bone histomorphometric properties and may prevent osteoporotic changes in diabetic rats.
【Fund】: 天津市卫生局科技基金项目(03KZ33)
【CateGory Index】: R587.1
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Chen Junhua Yang Liu Wan Xiying∥Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Effect of Xylitol on Blood Glucose and Insulin Release of the Patients with Diabetic Mellitus[J];Journal of Nursing Science;2002-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Guo-Ying Zhu, Yan-Yan Zhang, Shu-Zhu Gu and Xiao ChenDepartment of Environmental Epidemiology and Bone Toxicology, Institute of Radiation Medicine, Fudan University, Shanghai, 200032, P. R. China;Inhibitory effects of breast cancer cells on proliferation and differentiation of osteoblasts[J];Chinese Journal of Cancer;2009-05
2 YE Chao-qun1,JI Shu-rong2,ZHONG Xin-ming1 1.Section of Health & Rehabilitation,Capital Institute of Physical Education,Beijing 100088;2.Beijing Boai Hospital,Chinese Research Center of Rehabilitation,Beijing;The Bone Regulating Axle of RANKL-RANK-OPG[J];Journal of Capital Institute of Physical Education;2006-06
3 XIAO Yu-ming,SUN Xiu-juan,YU Yan-ni* (Department of Pathology,Guiyang Medical College,Guiyang 550004);Study of effect of fluoride on the expression of OPG,RANKL and RANK mRNA of rats with fluorosis and the antagonism of Danlan Xianpeng caspule[J];Chinese Journal of Control of Endemic Diseases;2010-04
4 GU Yan,ZHANG Qiao~* Department of Endocrinology,The First Hospital Affiliated to Guiyang Medical University,Guiyang 550004,China;Effects of lactoferrin on bone minernal density and bone structure in glucocorticoid-induced osteoporosis in rats[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2010-04
5 ZHU Guo-ying~(1*),CHEN Xiao~1,LI Min~2,et al 1.Institute of Radiation Medicine,Fudan University,Shanghai 200032;2.Shanghai Municipal Center for Disease Control & Prevention,Shanghai 200336,China;Studies on the standards for the bone mineral density measurement at forearm skeletal sites in the diagnosis of osteoporosis[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2010-04
6 LING Bing,ZHANG Qiao~* Department of Endocrinology,The First Hospital Affiliated to Guiyang Medical University,Guiyang 550004,China;The correlational research on levels of serum lactoferrin and bone mineral density in ovariectomized rats[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2011-01
7 Zuo Qingyao1,Liu Baoyue2,Deng Lili1(1.Department of Endocrinology and Metabolism;2.Department of Pathology, Beijing Ji Shui Tan Hospital,Beijing 100035,China);Clinical and pathological analysis of primary hyperparathyroidism in 85 cases[J];Chongqing Medicine;2012-20
8 YANG Jie,LI Yu-kun Second Department of Endocrinology,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;Bone morphogenetic protein and bone metabolism[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2013-01
9 KUANG Zhi-qiang1,ZHANG Rong-hua2* 1.Department of Rehabilitation,The First Affiliated Hospital of Jinan University,Guangzhou 510630,Guangdong,China 2.Department of Traditional Chinese Medicine,Pharmacy College of Jinan University,Guangzhou 510630,Guangdong,China;Effects of exercise combined with alendronate sodium tablets on RANKL/OPG balance and MAPK signaling pathways in ovariectomized rats[J];Academic Journal of Second Military Medical University;2013-08
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【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Feng Shi-min (DePartment of Phanmacy,Ninth People's Hospital,Shanghai Second Medical University);Xylitol:A Nex Source of Energy for Human Boay and Its Clinical Use[J];Chinese Journal of Hospital Pharmacy;1990-03
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