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《China Pharmacy》 2011-36
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Clinical Efficacy of Clopidogrel in the Treatment of Acute Coronary Syndrome and Effect of It on Serum Platelet P-selection and C-reactive Protein

ZHAO Zhu-fei(Dept.of Internal Medicine,Zhuji Municipal Second People's Hospital of Zhejiang Province,Zhuji 311811,China) WANG Fei(Dept.of Emergency,Zhuji Hospital of Traditional Chinese Medicine of Zhejiang Province,Zhuji 311800,China)  
OBJECTIVE:To observe the clinical efficacy of clopidogrel in the treatment of acute coronary syndrome(ACS),and to investigate the effects of it on serum platelet P-selection and C-reactive protein(CRP).METHODS:100 ACS patients were randomly divided into treatment group and control group.Control group was given conventional therapy of aspirin,and treatment group was given clopidogrel combined with conventional therapy of aspirin.The clinical efficacy was observed after treatment for 6 months.Before treatment and after treatment the serum platelet P-selection and CRP levels were detected.RESULTS:The total effective rate of treatment group was 94.0%,and that of control group was 76.0%,there was significant difference(P0.05).After treatment,the serum platelet P-selection and CRP levels of treatment group decreased significantly,compared with before treatment and control group the difference was significant(P0.05);The serum platelet P-selection and CRP were positive correlation(r=0.571,P=0.001).CONCLUSION:The serum platelet P-selection and CRP play an important role in the occurrence and disease progression of ACS.The clopidogrel therapy for CAS has obvious curative effect and can inhibit platelet activation and inflammatory response.
【CateGory Index】: R541.4
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【References】
Chinese Journal Full-text Database 1 Hits
1 TIAN Lei(The Affiliated Hospital of Xi'an Medical University,Shanxi Xi'an 710077,China);Influence of early Application of Loading Dose Clopidogrel for the Platelet Activity and Parameters of Patients with ACS[J];河北医学;2013-08
【Citations】
Chinese Journal Full-text Database 4 Hits
1 REN Yu-hua, ZHANG Xiao-gang(Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China);Role of Inflammation in Initiation and Progression of Atherosclerosis[J];心血管病学进展;2008-05
2 DONG Guo-ju, LIU Jian-gang, SHI Da-zhuo (Cardiovascular Department,Xiyuan Hospital of China Academy of TCM, Beijing 100091, China);Detection and Diagnosis of Unstable Atherosclerotic Plaque[J];心血管病学进展;2006-03
3 LI Hai-wen,YANG Zhi-ming,XIAO Chuan-shi(Department of Cardiology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China);Identification of Stability in Coronary Artery Atherosclerosis Plaque[J];心血管病学进展;2005-06
4 QU Xiao-bing*, SUN Zhen-qiu, CHEN Mei-juan, CHEN Long-long. *Departmentof Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011,China;The study of soluble P-selectin levels and it'scorrelation to the severity of coronary artery lesions in coronary heart disease[J];中华流行病学杂志;2005-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 BAI Juan;WANG De-qi;CAI Zhong-gui;Heart Medicine,Zaozhuang Mining Group Hospital;;The clinical application value of Homocysteine,D-dimmer and hypersensitive C-reactive protein in acute coronary syndrome[J];中国心血管病研究;2016-06
2 WU Kai-hong;Department of radiology in traditional Chinese Medicine Hospital;;A study of 64-layer spiral CT in analyzing the component of atherosclerosis plaques[J];齐齐哈尔医学院学报;2015-29
3 WANG He;GAO Haining;ZHAO Zelin;School of Kinesiology,Shenyang Sport University;;Effects of Long-term Winter Swimming Exercise on Elderly People's Sex Hormone and Serum Inflammatory Factors[J];沈阳体育学院学报;2015-05
4 TAO Yangu;LI Jinying;WEI Yanni;HUANG Qihui;Sun Yat-sen Memorial Hospital,Sun Yat-sen University;The Special Center of Henan Provincial People's Hospital;;Experimental Study of Shexiang Baoxin Pill in Preventing and Treating Atherosclerosis[J];中药新药与临床药理;2015-04
5 Zeng Qingna;Xu Jian;Huang Shan;Graduated of Guiyang Medical College;Clinical Laboratory Center of Guizhou Provincal People’s Hospital;Department of Cardiology,Guizhou Provincal People’s Hospital;Department of Radiology,Guizhou ProvincalPeople’s Hospital;;Two kinds of interleukins and the relationship between coronary artery calcium score[J];贵州医药;2014-12
6 WANG Zhi-jun;ZHANG Zhi-qiang;ZHANG Fang;HUANG Yu-ling;YANG Wen-qi;DIAO Zeng-li;LIU Tie-nan;LI Su-xin;Department of Cardiology,Affiliated Hospital of Hebei united University;;P-selectin levels analysis in patients with acute coronary syndromes[J];慢性病学杂志;2014-07
7 Yang Ronghai;Fang Changgeng;Liang Jianguang;Department of Cardiovascular Medicine,Sanshui People's Hospital of Foshan City;;The prognostic value of the combined detection of serum H-FABP and soluble P-selectin on short-term prognosis in patients with acute myocardial infarction(AMI)[J];广州医科大学学报;2014-04
8 WU Xuebing;YU Zhiliang;WANG Xinhua;LI Bu;SHEN Haitao;HANG Haiyan;Fu Buqing;Department of Laboratory,Shanghai Seventh People's Hospital;Department of Neurology,Shanghai Seventh People's Hospital;Department of Renal Medicine,Shanghai Seventh People's Hospital;Department of Laboratory Medicine of Jiangsu Province Hospital of TCM;;Analysis of Relationship between TCM Syndromes of Acute Cerebral Infarction and Red Blood Cell and Platelet Parameters[J];辽宁中医杂志;2014-08
9 WANG He;LIANG Qiaoqin;School of Sports Science,Shenyang Sport University;School of Physical and Health,Guizhou University for Nationalities;;Effects of Low Temperature Swimming on Aorta Structure and CRP,IL-6,ET in Atherosclerosis Rats[J];沈阳体育学院学报;2014-02
10 YANG Li;HUANG Yi;LUO Li;Department of Cardiology,the First People' Hospital;;Clinical study of P-selectin, Hs-CRP and acute coronary syndrome[J];中国现代医学杂志;2014-08
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 CHEN Zhang-qiang,HONG Lang,WANG Hong,et al.Department of Cardiology of Jiangxi province people′s hospital,Cardiovascular disease institute of Jiangxi Province,Nanchang 330006,China;Effects of High Loading Dose and High Maintenance Doses of Atorvastatin on Platelet Activity,Vascular Endothelium Function,Inflammation and Prognosis in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention[J];中国全科医学;2012-23
2 SHI Wen-bing1,FU Dao-cun1,ZHENG Xiao-kun2,WANG Ying3(1.Department of Cardiology,Shandong Red Cross-Dongda Hospital,Jinan 274300,Shandong,China;2.Shilou Central Hospital,Shan County,Shan 273715,Sandong,China;3.Heze Vocational School of Home Economics,Heze 274300,Shandong,China);Effect of increased dosage of aspirin and clopidogrel on major adverse cardiovascular events in early treatment of patients with acute coronary syndrome[J];心脏杂志;2011-06
3 ZHAO Zhu-fei(Dept.of Internal Medicine,Zhuji Municipal Second People's Hospital of Zhejiang Province,Zhuji 311811,China) WANG Fei(Dept.of Emergency,Zhuji Hospital of Traditional Chinese Medicine of Zhejiang Province,Zhuji 311800,China);Clinical Efficacy of Clopidogrel in the Treatment of Acute Coronary Syndrome and Effect of It on Serum Platelet P-selection and C-reactive Protein[J];中国药房;2011-36
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Guo Sanqiang;Han Shengbo;Zhang Junpeng;Li Min;Department of Cardiology,Hospital of Zhengzhou City;;The improvement of Shexiang Baoxin Pill for clopidogrel resistance on patients with acute coronary syndrome[J];中药药理与临床;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 XIANG Zi-yun1, ZHU Pin-xian2 (Long Gang Peoples Hospital,1. Deportment of Radiology;2. Deportment of Cardiology, Shenzhen; Guang-dong, Shenzhen 518172, China);Clinical Application of Multi-Slice CT Virtual Intravascular Endoscopy in Diagnosis of Arteriosclerosis[J];CT理论与应用研究;2004-02
2 Chen Wenqiang,Zhang Yun,Zhang Mei,et al Department of Cardiology,Qilu Hospital of Shandong University,Jinan 250012 China;Clinical Study on Intravascular Ultrasonic Features of Unstable Atherosclerotic Plaques[J];中国超声医学杂志;2004-04
3 CHEN Ji-yan, YU Dan-qing, ZHOU Ying-ling, et al.Deparment of Cardiology,Guangdong Provincial Cardiovascular Research Institute,Guangzhou 510008,China;Clinical analysis on vulnerable coronary atherosclerotic plaque by intravascular ultrasound[J];中华超声影像学杂志;2003-12
4 LI Yanhui ,MENG Xiaoping,QU Ling. The Second Hospital of Jilin Univercity,Changchun 130041,China;Serum levels of matrix metalloproteases-2 are elevated in acute myocardial infarction[J];中华急诊医学杂志;2003-04
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