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《China Pharmacy》 2012-16
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Clinical Observation of Cinobufacini Injection Combined with TP Regimen for Advanced Non-small-cell Lung Cancer

HU Zhang-hua(Neijiang Municipal First People's Hospital of Sichuan Province,Sichuan Neijiang 643000,China)  
OBJECTIVE:To observe the clinical efficacy of Cinobufacini injection combined with TP regimen for advanced non-small-cell lung cancer(NSCLC)and the tolerance of patients.METHODS:74 cases of advanced non-small-cell lung cancer were randomly divided into observation group(36 cases)and control group(38 cases).All of them received TP regimen(Paclitaxel injection 135 mg·m-2 ivgtt,d1,combined with cisplatin 75 mg·m-2 ivgtt,d2)as well as systemic chemotherapy.The treatment duration was divided into 4 to 6 periods,which lasted for 21 days per period.Observation group received chemotherapy and was treated with Cinobufacini injection 20 mL·d-1,d1~14 at the same time.The therapeutic efficacy,quality of life,and adverse toxic reaction were evaluated.RESULTS:The response rates of 2 groups were 55.6% and 36.8%,respectively.There was statistical significance in the difference of recent therapeutic efficacy between 2 groups(P0.05).The quality of life had a significant difference between 2 groups(P0.05).The major adverse drug reactions were gastrointestinal reactions and hematological toxicity,and those of observation group had a lower rate than the control group(P0.05).And the median survival time of observation group was 10 months while the control group's was 8 months.The difference was statistically significant(P0.05).CONCLUSIONS:Cinobufacini injections combined with TP scheme has a good therapeutic efficacy of NSCLC,and it can improve the patient's quality of life and reduce any toxic reaction.
【CateGory Index】: R734.2
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