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《China Pharmacy》 2013-44
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A Systematic Review of Therapeutic Efficacy and Safety of Adjuvant Therapy of Compound Sophora flavescens Injection in the Treatment of Tumor

SU Rui;LI Ling;XU Hong-bin;HUANG Fang;Anhui University of TCM;The Affiliated Tenth People's Hospital,Tong ji University;  
OBJECTIVE:To evaluate therapeutic efficacy and safety of Compound Sophora flavescens injection in the treatment of tumor. METHODS:Retrieved from Cochrane Centre Database,Medline,EMbase,CBM,CNKI,Cochrane Controlled Trials Register,SWIC and Wanfang database during Oct. 2012,RCTs about Compound S. flavescens injection combined with chemotherapy vs. chemotherapy alone were collected. Data were extracted and evaluated by two reviewers independently with designed extraction form and Rev Man 5.0 software was used for data analysis. RESULTS:82 RCTs were included,invovling 5 921 patients. Meta-analysis showed that Compound S. flavescens injection combined with chemotherpy can imporve total response rate[RR=1.36,95%CI(1.29,1.44),P0.01],clinical benefit response [RR=1.39,95%CI(1.29,1.50),P0.01],KPS [RR=1.65,95%CI(1.52,1.78),P0.01],1 year survival rate [RR=1.41,95%CI(1.23,1.63),P0.01] and 2 year survival rate [RR=1.75,95%CI(1.23,2.48),P0.01] significantly,reduced toxic side effect and improve patient's tolerance. CONCLUSIONS:Compound S. flavescens injection combined with chemotherapy in the treatment of tumor improves the short-term curative effect,clinical benefit and life quality,and decrease the toxicity of chemotherapy. High quality randomized controlled trials should be performed due to the low quality of included trials.
【Fund】: 上海市药学会上海医院药学科研基金资助项目(No.2012-YY-01-02)
【CateGory Index】: R730.5
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