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《China Preventive Medicine》 2005-06
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Effects of High Fluoride and Low Iodine on Learning-Memory and TchE of Brain in Offspring Rats

HONG Jian-hua~*,GE Ya-ming,NING Hong-mei,et al.~The Hospital of Shanxi Agricultural University,Taigu,Shanxi 030801,China  
Objective To study the effect of high level fluoride and low level iodine on learning-memory in offspring rats and possible mechanism. Methods Thirty-two Wistar rats were randomly divided into four groups each of eight(female:male=(3∶1).)The rats were treated with high fluoride(100 and 150 mg NaF/L),low iodine(0.0855 mg/kg),or broth high fluoride(100 and 150 mg NaF/L)and low iodine(0.0855 mg/kg)respectively.Results Compared with control rats,error number(EN1)and(EN2)of the experimental offspring rats increased significantly(P0.05).Sustaining time(ST)reduced obviously(P0.05).EN1 and EN2 of the experimental rats in the group of high