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《Journal of China Pharmaceutical University》 2004-03
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Determination of Huperzine A in Beagle Dog Plasma by HPLC/MS/MS Method

FU Xu-Dong 1,PING Qi-Neng 1,GAO Yong-Liang 2,GUO Ji-Fen 2 ( 1Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China; 2 Institute of Pharmacology and Toxicology,The Academy of Military Sciences,Beijing 100850,China)  
AIM:To develop HPLC-MS-MS method for the quantification of huperzine A in beagle dog plasma. METHOD:Samples were extracted by liquid-liquid extraction and seperared on a Nucleocil ODS column.The mobile phase is MeOH-CH_ 3 CN-H_2O-HCOOH(20∶40∶40∶0.1, v/v ).Flow rate was 0.2 ml/min.Quantitation was based on multiple reactin monitoring (MRM) using the precursor→product ion combinations of m/z 243→210 and m/z 257→226 for the huperzine A and N -methyl huperzine A respectively.RESULT:The assay range of this method is 0.1~12 ng/ml.The limit of quantification was 0.1 ng/ml.Huperzine A in beagle plasma at 12h after administration of 100 μg via the iv and po could be detected.CONCLUSION:The method is sensitive,simple and rapid.It can be applied to study the pharmacokinetics of huperzine A.
【CateGory Index】: R96
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