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《Journal of China Pharmaceutical University》 2006-01
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A rat metabolic syndrome model induced by stress accompanying high-glucose-fat-diet

SU Chang-hai,FU Ji-hua,SHAN Ying,KONG Shu-jia,WANG YuanDepartment of Physiology,China Pharmaceutical University,Nanjing 210009,China  
Aim:To develop an animal model that could show typical characteristics of Metabolic Syndrome(MS) by multifactorial effects and be expected for application in the study of the mechanisms and therapeutic drug of MS.Methods: The model was established by stress in male Wistar rats combined with high-sugar-fat-diet.The stresses included foot-shock with addition of noise stimulation.The animals were randomly divided into four groups: group A(normal diet),group B(high-glucose-fat-diet),group C(normal diet + stress),group D(high-glucose-fat-diet + stress).In 55 days,group C and D received two times of daily stress,which lasted 2 hours each time,in the morning and afternoon,going on for 55 days.Blood pressure was examined,and body weight as well as food intake were measured every week.Plasma lipoprotein and plasma glucose were assayed after 45 days of stress,and glucose tolerance test(GTT) was evaluated after 55 days.Results: During the 6-week stress,the food intake and blood pressure of both groups C and D were elevated significantly,but there was no statistical difference between the two groups.The extent of increase in the body weight was found to be small after the 4-week stress on group D.Compared with group A,hyperglycemia took place in group D rather than groups B and C.The levels of TC、LDL、VLDL、TC/HDL、(LDL+VLDL)/HDL were found to be markedly increased in group D,and higher than those occurred to groups B and C.Furthermore,a statistically significant reduction in HDL in the group D was observed in comparison to the group A.However,the extent of increase in TG in the group D is less than the group B.GTT abnormity in the group D was the most obvious among these groups.Conclusion:The model of combining high-glucose-fat-diet with stress could cause significant dyslipidemia,hypertension,light hyperglycemia and GTT abnormity.The stress combination might exert the synergistic effects on the developed model,rather than the additive superimposition of each other.
【CateGory Index】: R-332
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