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《Chinese Journal of Medicinal Chemistry》 2002-04
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Studies on the synthesis and antibacterial activity of quinolone analogues

QU Ling bo,TIAN Meng chao,CHANG Jun biao,CHEN Rong feng,GUO Zong ru (Department of Chemistry,Zhengzhou University,Zhengzou 450052,China)  
Aim To design and synthesize a series of new anaerobic compounds of quinolone.Method 1 iodoethyl 2 methyl 5 nitro imidazole was obtained from 1 hydroxyethyl 2 methyl 5 nitro imidazole.A series of novel analogues of quinolones was prepared by the reaction of 1 iodoethyl 2 methyl 5 nitro imidazole with 1 alkyl 6 fluoro 7 (4 substituted 1 piperazinyl) 1,4 dihydro 4 oxo quinoline 3 carboxylic acid.Conclusion Sixteen new compounds were synthesized and their structures were confirmed by 1H NMR and elementary analysis.Antibacterial activity in vitro and in vivo was tested.Two of the compounds showed higher activity than the compared compounds in vivo .
【Fund】: 河南省杰出青年基金资助项目 (990 13 )
【CateGory Index】: R914
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