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《Chinese Journal of Medicinal Chemistry》 2002-05
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Syntheses and antibacterial activity of 1-alkyl-6-fluoro-7-(4-acyl-1-piperazinyl)-1,4-dihydro-4-oxo- quinoline-3-carboxylic acid and its derivatives

TIAN Meng chao,QU Ling bo,XIE Jian gang,CHEN Rong feng (Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China)  
Aim To synthesize new fluoroquinolone analogues as antibacterials.Methods By the reaction of the fluoroquinolone analogues with chlorides of the acid,the chloro carbonic ester under the condition of Schotten Baumann,20 fluoroquinolone analogues,including 16 new compounds were prepared.Results The structures of the synthesized compounds were determined by 1H NMR and elementary analysis.Inhibiting activity in vitro was tested.Conclusion The 16 compounds prepared were new compounds and 4 of them showed higher activity than those of the compared compound.
【Fund】: 河南省杰出青年基金资助项目 (9913)
【CateGory Index】: R914
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