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《Chinese Journal of Medicinal Chemistry》 2003-01
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Improved synthesis of 2-amino-5-methylthiazole

ZHANG Zhi-guo,ZHANG Yi-hua,LI Ya-jing (Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China)  
2-Amino-5-methylthiazole,a key intermediate for the synthesis of meloxicam,was prepared from n-propanol by oxidation and chlorination with hypochlorous acid,followed by condensation with thiourea in an overall yield of 55%.
【CateGory Index】: TQ465
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Chinese Journal Full-text Database 1 Hits
1 LIAN Hui-Qing,LIU Rui-Quan~(*),ZHU Li-Qin,WANG Ji-De (College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046);Inhibition Corrosion of Thiazole Derivatives on A_3 Steel in 1 mol/L HCl Solution[J];Chinese Journal of Applied Chemistry;2006-06
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1 WANG Yu Cheng, SHI Da Qing, ZHAO Hong, DAI Gui Yuan (Dept. of Chemistry, Xuzhou Normal University, Xuzhou 221009);Synthesis of Meloxicam[J];Chinese Journal of Pharmaceuticals;2001-06
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1 WU Fan hong *, WANG Bao dan, XI Guan gen (College of Chemistry and Pharmaceutics ECUST, Shanghai 200237, China)$$$$;Synthesis of Meloxicam and Piroxicam[J];Journal of East China University of Science and Technology;2002-03
2 RU De xin (College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China);Study on the Synthesis and Using of 2-Amino-5-Methylthiazole[J];Chemical Reaction Engineering and Technology;2002-01
3 LIU Wei,LI Mao-lin,LIU Jin-Qiang,CHENG Ren-bing,CHEN Xinzhi(College of Material Science and Chemical Engineering,Zhejiang University,Hangzhou 310027,China);Synthesis of the Intermediates for Tinoxicam[J];Fine and Specialty Chemicals;2005-19
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1 WANG Peng,XIN Fei,Li Hai-hua,DU Xi-ying (School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing100081, China);Preparation of 4-Methyl-5-(β-Hydroxyethyl)-Thiazole[J];Journal of Beijing Institute of Technology;2004-09
2 QU Rongjun 1,2* , SUN Changmei 2, WANG Chunhua 2, JI Chunnuan 2, CHENG Guoxiang 1(1 School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China; 2 School of Chemistry and Materials Science, Yantai Normal University, Yantai 264025, Shandong, China);Polymer Synthesis by Phase-Transfer Catalysis[J];Chinese Journal of Catalysis;2003-09
3 QU Yan-ping, SONG Ying-wei, LI De-gao, TIAN Jian-jun, YAN Ping ( School of Material Science and Engineering, Shenyang University of Technology, Shenyang 110023; Shenyang Institute of Foundry, Shenyang 110022, China);Technology and Characteristics of Electroless Ni-P-TiO_2(nanometer) Composite Plating[J];Materials Protection;2003-04
4 YU Hui-hua, ZHANG Jing, DU Min(School of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100,China).;Application of Quantum Chemical Methods in Study of Corrosion Inhibitors[J];Materials Protection;2010-11
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10 LEI Zhi-gang1,ZHENG Chuan-ming1,HAN Rong-sheng2,ZHU Guang-dong1,HE Guo-xu1(1.School of Science,Beijing Institute of Technology,Beijing 100081,China;2.Physics & Chemistry Experiment Center,Academy of Armored Forces Engineering,Beijing 100072,China);INFLUENCE OF FOUR STABILIZERS ON ELECTROLESS Ni-P SOLUTION AND CORROSION RESISTANCE OF Ni-P COATING[J];Corrosion & Protection;2007-03
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