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《Chinese Journal of Medicinal Chemistry》 2003-01
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Improved synthesis of 2-amino-5-methylthiazole

ZHANG Zhi-guo,ZHANG Yi-hua,LI Ya-jing (Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China)  
2-Amino-5-methylthiazole,a key intermediate for the synthesis of meloxicam,was prepared from n-propanol by oxidation and chlorination with hypochlorous acid,followed by condensation with thiourea in an overall yield of 55%.
【Key Words】: medicinal chemistry process improvement process research 2-amino-5-methylthiazole meloxicam
【CateGory Index】: TQ465
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIAN Hui-Qing,LIU Rui-Quan~(*),ZHU Li-Qin,WANG Ji-De (College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046);Inhibition Corrosion of Thiazole Derivatives on A_3 Steel in 1 mol/L HCl Solution[J];Chinese Journal of Applied Chemistry;2006-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Yu Cheng, SHI Da Qing, ZHAO Hong, DAI Gui Yuan (Dept. of Chemistry, Xuzhou Normal University, Xuzhou 221009);Synthesis of Meloxicam[J];Chinese Journal of Pharmaceuticals;2001-06
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 WU Fan hong *, WANG Bao dan, XI Guan gen (College of Chemistry and Pharmaceutics ECUST, Shanghai 200237, China)$$$$;Synthesis of Meloxicam and Piroxicam[J];Journal of East China University of Science and Technology;2002-03
2 RU De xin (College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China);Study on the Synthesis and Using of 2-Amino-5-Methylthiazole[J];Chemical Reaction Engineering and Technology;2002-01
3 LIU Wei,LI Mao-lin,LIU Jin-Qiang,CHENG Ren-bing,CHEN Xinzhi(College of Material Science and Chemical Engineering,Zhejiang University,Hangzhou 310027,China);Synthesis of the Intermediates for Tinoxicam[J];Fine and Specialty Chemicals;2005-19
4 YANG Li ying, HE Zhong gui, WANG Li wen, LI Hao zhi (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China);RP-HPLC determination of meloxicam and its related substances in the meloxicam injection[J];Journal of Shenyang Pharmaceutical University;2003-03
5 WEN Yan-Zhen, WEI Wen-Long, GAO Zhi-Wei (Dept. of Biological and Pharmaceutical Engineering, College of Chemical Engineering and Technology, Taiyuan University of Technology, Taiyuan 030024);Synthesis of Meloxicam[J];Chinese Journal of Pharmaceuticals;2005-06
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Chinese Journal Full-text Database 10 Hits
1 QU Yan-ping, SONG Ying-wei, LI De-gao, TIAN Jian-jun, YAN Ping ( School of Material Science and Engineering, Shenyang University of Technology, Shenyang 110023; Shenyang Institute of Foundry, Shenyang 110022, China);Technology and Characteristics of Electroless Ni-P-TiO_2(nanometer) Composite Plating[J];Materials Protection;2003-04
2 ZHANG Qin-fa, HE Lun-ying, HE Xin-Kuai, DUAN Chun ( Institute of Packaging & Printing, ZhuZhou Engineering college, ZhuZhou 412008; China-German Packaging & Printing Polytechnic Institute, Hefei 230001, China);Physical and Inhibition Properties of Dicyclohexylamine Nitrite and Volcanic Ash Tablet[J];Materials Protection;2003-04
3 HE Wei, TANG Xian zhong, CHI Lan zhou (Chemistry Dept., Electronical Technology Univ., Chengdu 610054, China);Study of electroless nickel plating on surface of carbon fibre[J];Electroplating & Finishing;2003-01
4 Translated and Compiled by WANG Li-li;Displacement Type Silver Electroless Plating Bath[J];Plating and Finishing;2003-01
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10 LU Jing-Ci, CHEN Jun-Sheng, SU Qing-De (Department of Applied Chemistry, University of Science and Technology of China, Hefei, 230026)YONG Ke-Lan (Petrolium Chemical Exploration Center of MGMR,Hefei, 230022);Synthesis and Characterization of Lathanum Complex with 8-Hydroxyquinoline by Solid State Reaction[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;1997-08
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1 LI Dong,LIU Shuai,ZANG Chong-guang,YANG Shuo,JIAO Qing-jie(State Key Laboratory of Explosion Science and Technology,Beijing Institute of Technology,Beijing 100081,China);On the formulas of flame-retardant low-density polyethylene films by using orthogonal plan method[J];Journal of Safety and Environment;2005-06
2 He Yunzhao,He Lida,Peng Shuangfei(Department of Environmental Engineering,Xiangtan University,Hunan Xiangtan 411105,China);A Review on the Methods of Industrially Producing Thiourea with the Tail Gas Containing Hydrogen Sulfide[J];Guangdong Chemical Industry;2009-11
3 QI Xin,WANG Qian,LI Zhong-bo,LI Wen-feng(School of Sciences,Tianjin University,Tianjin 300072,China);New Process for Producing Thiourea from Urea[J];Chemical Industry and Engineering;2006-05
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1 HE Jian-xiong (Shenzhen Pharmaceutical Factory,Guangdong);IMPROVEMENT OF PIROXICAM SYNTHESIS[J];;1987-12
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