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Synthesis and antibacterial activity of norfloxacin derivatives

YE Fa-qing 1,DING You-mei 1,YE Song 2,YUAN Xin 2 (1.Department of Pharmaceutical Chemistry,Wenzhou Medical College,Wenzhou 325027,China; 2.Department of Pharmacy,Xianning Medical College,Xianning 437100,China)  
Aim To study the synthesis and antibacterial activity of norfloxacin derivatives.Method Norfloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol,norfloxacin via nucleophilic substitution.The antibacterial activities of the nine target compounds were tested.Result Their structures were confirmed by 1H-NMR,MS and elemental analysis.Conclusion The nine compounds prepared were new compounds and three of them showed higher activity than those of the compared compounds.
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