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《Chinese Journal of Medicinal Chemistry》 2003-03
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Synthesis and antibacterial activity of norfloxacin derivatives

YE Fa-qing 1,DING You-mei 1,YE Song 2,YUAN Xin 2 (1.Department of Pharmaceutical Chemistry,Wenzhou Medical College,Wenzhou 325027,China; 2.Department of Pharmacy,Xianning Medical College,Xianning 437100,China)  
Aim To study the synthesis and antibacterial activity of norfloxacin derivatives.Method Norfloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol,norfloxacin via nucleophilic substitution.The antibacterial activities of the nine target compounds were tested.Result Their structures were confirmed by 1H-NMR,MS and elemental analysis.Conclusion The nine compounds prepared were new compounds and three of them showed higher activity than those of the compared compounds.
【CateGory Index】: R914
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【References】
Chinese Journal Full-text Database 1 Hits
1 SHI Mei,CHEN Chang-yun,LU Guo-fei(School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing 211171,Jiangsu);Synthesis of Norfloxacin Derivative under Microwave Irradiation[J];南京晓庄学院学报;2010-06
【Citations】
Chinese Journal Full-text Database 3 Hits
1 YE Fa qing,CHEN Li,HUANG Jin min,HU Fei,XIA Feng,HE Tao,ZHANG Xiao li (Department of Pharmaceutical Chemistry,Xianning Medical College,Xianning 437100,China);Synthesis of 1-(2′-Bromoethyl)-2-methyl-5-nitroimidazole[J];精细化工;2002-04
2 WANG Dun-jia DU Dong-yun (Department of Chemistry,Hubei Normal University,Hubei Huangshi 435002);IMPROVED PROCESS OF NORFLOXACIN[J];湖北师范学院学报(自然科学版);2000-02
3 GUO Hui-Yuan, TANG Yun, LI Zhuo-Rong, YAN Gui-Hua and ZHANG Zhi-Ping (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing);STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS V. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIVALOYLOXYMETHYL 1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXO-7-(4-METHYL-1-PIPERAZINYL) QUINOLINE-3-CARBOXYLATE AND ITS ANALOGUES[J];药学学报;1987-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Man;XIE Shuyuan;MENG Rongqian;Department of Chemistry and Chemical,Taiyuan Institute of Technology;;Norfloxacin derivatives synthetic feasibility analysis[J];山西化工;2015-01
2 Yang,Jiaqiang;Hu,Yuewei;Gu,Qing;Li,Minggang;Li,Mingqiang;Song,Baoan;School of Pharmacy,Zunyi Medical College;Laboratory of Microbiology and Immunology,Zunyi Medical College;Center for Research and Development of Fine Chemicals,Guizhou University;;Synthesis and Antibacterial Activities of Novel Phosphonate Derivatives Containing Quinolinone Moiety[J];有机化学;2014-04
3 ZHANG Yan;ZHENG Tu-cai;XU Xiang-sheng;College of Chemical and Materrial Engineering,Qu Zhou University;Institute of chemical engineering and material,Zhejiang University of Technology;;Applied Research of Diethyl Ehoxymethylenemalonate[J];山东化工;2013-10
4 Zhang Yan;Zheng Tucai;College of Chemical and Material Engineering, Quzhou University;;Applied Research Progress of Diethyl Ethoxymethylenemalonate[J];化工生产与技术;2013-04
5 SONG Lei,WANG Jian-long,LI Yong-xiang,WANG Xiao-jun,CAO Duan-lin(Department of Chemical Engineering,North University of China,Taiyuan 030051,China);Synthesis and Characterization of 1-Methyl-4,5-dinitroimidazole[J];含能材料;2009-05
6 LI Jian-yong et al(Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences,CAAS,Lanzhou,Gansu 730050);Pharmacokinetics of Junmie for Novel Antibacterial Medicine in Rabbit[J];安徽农业科学;2009-18
7 WANG Xiao-jun,YANG Cai-yun ,SONG Lei ,CAO Duan-lin,LI Yong-xiang,WANG Jian-long(College of Chemical Engineering and Environment,North University of China,Taiyuan 030051,China);Progress in the New Engergetic Materials of 1-Methyl-2,4,5-Trinitroimidazoles[J];山东化工;2009-05
8 LI Jian-yong1, 2*, TANG Feng3, ZHOU Xu-zheng1, 2, ZHANG Ji-yu1, 2, NIU Jian-rong1, 2, WEI Xiao-juan1, 2, YANG Ya-jun1, 2 1. Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences, CAAS, Lanzhou 730050, China; 2. Key Lab of New Animal Drug Project, CAAS, Lanzhou 730050, China; 3. Animal Science and Veterinary Medicine, Liaoning College of Medicine, Jinzhou 121000, China;Pharmacokinetics of Junmie for Novel Antibacterial Medicine in Rabbits[J];Animal Husbandry and Feed Science;2009-03
9 Wang Xiaojun Song Lei Cao Duanlin Li Yongxiang Wang Jianlong (College of Chemical Engineering and Environment, North University of China, Taiyuan 030051, Shanxi, China);Progress in the Low Insensitive Explosive of 1-Methyl-2,4, 5-Trinitroimidazoles[J];化工中间体;2009-03
10 LI Jian-yong,LI Hong-sheng,ZHOU Xu-zheng,ZHANG Ji-yu,NIU Jian-rong,LI Jin-shan,WEI Xiao-juan(Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences,CAAS,Lanzhou,Gansu,730050,China);Primary Test on Activity of Junmie Against Bacteria[J];动物医学进展;2006-08
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 YE Fa-qing 1,DING You-mei 1,YE Song 2,YUAN Xin 2 (1.Department of Pharmaceutical Chemistry,Wenzhou Medical College,Wenzhou 325027,China; 2.Department of Pharmacy,Xianning Medical College,Xianning 437100,China);Synthesis and antibacterial activity of norfloxacin derivatives[J];中国药物化学杂志;2003-03
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Sun Lu,Xu Rongfang,Chen Changyun,Chen Quanzhan,Shi Mei School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing,China 211171;Coordination Reaction and Antibacterial Activity of Rare Earth with Norfloxacin Derivative[J];中国教育技术装备;2011-18
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Guo Hongbin,Cai Min,Chen Tao,Li Fengling Research Institute,Northeast No.6 Pharmaceutical Factory,Shenyang 110043;An Improved Synthesis of Tinidazole[J];沈阳药科大学学报;1999-02
2 JI Geng-Hao (Shenzhen Sinor Pharmaceutical Co.Ltd.Guangdong 518003);SURVEY ON SYNTHETIC PROCESS OF NORFLOXACIN[J];中国医药工业杂志;1992-03
3 Zhang Zhi-ping (Institute of Antibiotics. Chinese Academy of Medical Sciences, Beijing);PROGRESS IN STUDIES ON TOTAL SYNTHESES OF ANTIBIOTICS AND ANTIMICROBIAL AGENTS IN THE 1980S.[J];抗生素;1985-03
4 Zhang Zhen, Yen Min and Lei Xnghan (Shanghai Institute of Pharmaceutical Industrial Research);CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVES[J];药学学报;1981-07
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