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《Chinese Journal of Medicinal Chemistry》 2009-03
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Triterpenoidal constituents of Pericampylus glaucus and their antitumor activity in vitro

ZHAO Wei-quan,CUI Cheng-bin(Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)  
Aim To investigate triterpenoidal constituents of Pericampylus glaucus(Lam.)Merr.and to eva-luate their antitumor activities.Methods Various chromatographic means were used for the isolation of triterpenes and the compounds obtained were identified by the spectroscopic method.Antitumor activities were also assayed by MTT method.Results Five triterpenes were isolated from Pericampylus glaucus and identified as hopenone-B(1),hopenol-B(2),22-hydroxyhopan-3-one(3),erythrodiol 3-palmitate(4),and 5β,24-cyclofriedelan-3-one(5),respectively.Among them,compound 4 inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 μg·mL-1,while others did not show inhibitory effect at the concentration tested.Conclusion Compounds 1-5 were isolated from the genus Pericampylus for the first time.Compound 4 is the first reported antitumor constituent of Pericampylus glaucus and its antitumor activity was also assayed for the first time.The 13C-NMR data for 2 and the 1H-NMR and 13C-NMR data for 1 and 5 were reported for the first time.
【Fund】: 国家重点基础研究发展规划项目(2006CB504100&1998051113);; 国家自然科学基金项目(39825126)
【CateGory Index】: R284.1
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