Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of China Medical University》 2012-02
Add to Favorite Get Latest Update

Effect of Shenfu Injection on MDA,SOD,TXB_2 and 6-keto-PGF1a after Cerebral Ischemia/Reperfusion Injury in Rats

JIANG Cheng-ping1,LIU Fu1,LI Yi1,WANG Bai-qiang1,TANG Xiao-rong1,WU Bi-hua2,WANG Xiao-ming2(1.Department of Pharmacology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637007,China;2.Neurology Research Institute,North Sichuan Medical College,Nanchong 637007,China)  
Objective To investigate the effect of Shenfu injection on the MDA,SOD,TXB2 and 6-keto-PGF1a after cerebral ischemia/reperfusion injury in rats.Methods Sixty male SD rats were randomly divided into three groups:Sham group(Sham group,n =20);encephalic ischemia reperfusion group(IR group,n =20) and Shenfu pretreatment group(SFI group,n =20).Reversible middle cerebral artery occlusion(MCAO) models were produced by intraluminal suture technique.The extent of neurological deficits was evaluated by Longa method;the infarct area of brain was measured by 2,3,5-triphenyl tetrazolium chloride(TTC) staining technique;while the changes of MDA,SOD,TXB2 and 6-keto-PGF1a were detected in plasma.Results Shenfu injection could effectively improve the symptoms of neurological deficits and significantly diminish the infarct areas of brain of MCAO in rats.Compared with sham operation group,MDA,TXB2 increased(P 0.05),SOD and 6-keto-PGF1a decreased(P 0.05) in IR group.Compared with IR group,MDA,TXB2 decreased(P 0.05),SOD and 6-keto-PGF1a increased in Shenfu pretreatment group(P 0.05).Conclusion Shenfu injection has a protective effect on the brain injury induced by ischemia.Its mechanism is correlated with the anti-radical effects.And it can maintain a balance between TXB2 and 6-keto-PGF1a.
【Fund】: 四川省科技厅资助项目(2010JY0094)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Qinglan,Ren Zeen,Wu Jiankun,et al.Department of Neurology,changzhi's iron and steel group company general hospital;Protective Effects of Luotai Injection on Local Cerebral Ischemia and Reperfusion Injury in Rats[J];Journal of Changzhi Medical College;2008-03
2 LUO Yong, et al (Department of Neurology, College of Clinical Medicine, Chongqing Medical University);An experimental study on focal cerebral ischemia/reperfusion model in Wistar rats with suture method[J];Acta Universitatis Scientiae Medicinae;2002-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WU Xiao guang,YAN Yong,JIN Hong wei (Institute of Basic Medicine, Chengde Medical College, Hebei Chengde 067000, China);THE BUILD OF FOCAL CEREBRAL ISCHEMIA /REPERFUSION MODEL IN MOUSE WITH SUTURE METHOD[J];Journal of Chengde Medical College;2003-04
2 WAN Dong,LUO Yong (Department of Neurology,the first Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);The phenomenon of nuclear factor-κB nuclear translocation and its significance in brain tissue of Wistar rats subjected to focal cerebral ischemia/reperfusion[J];Chongqing Medical Journal;2003-11
3 GONG Biao,LI Chang-qing,HUANG Jian(1.TCM College Chongqing University of Medical Sciences,Chongqing 400050,China;2.Second Hospital Affiliated to Chongqing University of Medical Sciences,Chongqing 400010,China);Modification of suture methods for rat model of focal cerebral ischemia/reperfusion[J];Chongqing Medicine;2006-04
4 Zhang Shanshan, Luo Yong, Wu Lei (Department of Neurology, Chongqing Key Laboratory of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China);Role of phosphoinositide 3-kinase/AKT signaling pathway in promoting angiogenesis in rats with focal cerebral ischemia/reperfusion using electrical acupuncture[J];Acta Academiae Medicinae Militaris Tertiae;2010-23
5 ZHU Ji1, WAN Dong2, TANG Wen-Yuan11Department of Neurosurgery, 2Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China;Application of modified suture in preparation of rat model of focal cerebral ischemia[J];Journal of the Fourth Military Medical University;2008-08
6 GONG Jia-Ming,LUO Yong,WANG Yong-Long,HE Lan-Ying,CAI Zhi-You Department of Neurology,First Affiliated Hospital,Chongqing University of Medical Scineces,Key Laboratory of Neurology in Chongqing,Chongqing 400016,China;Expression of C-Rel and Bcl-xL in rat brain with focal cerebral ischemia-reperfusion and its significance[J];Journal of the Fourth Military Medical University;2009-04
7 GONG Jia-Ming,LUO Yong,JIANG Kai-fu,LIU Yi.Department of Neurology,Ankang City Central hospital,Shanxi 725000,China;Effects of Electrical Stimulation to the Cerebellar Fastigial Nucleus on the Expression of NF-κB and MMP-9 after Focal Cerebral Ischemia in Rats[J];Neural Injury and Functional Reconstruction;2010-01
8 ZHANG Qing-ping1, TAN Lu-lu2,LIU tai (1.Department of neuro-internal medicine, the first affiliated hospital of guangxi TCM university,nanning 530023 2.Graduates in guangxi Traditional Chinese Medicine unniveristy, nanning, 530001);Protective effects of xingnaotongmai capsules against the cerebral damage in the rat experienced focal cerebral ischemia[J];Guangxi Journal of Traditional Chinese Medicine;2008-05
9 BI Fang-fang, TIAN Fa-fa *, YANG Qi-dong,XIAO Bo (Department of Neurology, Xiangya Hospital,Central South University, Changsha 410008,China);Establishment and judgement of the animal model of focal ischemia-reperfusion[J];;2004-06
10 MA Zhi-jian,LUO Gang,YI Xi-nan(Department of Anatomy,Hainan Medical College HaiKou 571101,China);Establishment and judgement of the animal model of cerebral ischemia-reperfusion[J];Journal of Hainan Medical College;2009-06
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 LI DONG-LIANG (Department of Physiology, Xinxiang Medical College)CHENG XIAO-HONG(Department of Physiology, medical Institution of the General Logistics Departement in P. L. A. )SHEN HONG HUA ZHONG-WEI LI YU-SHU(Institute of Basic Medical Science. Academy of Military Medical Sciences);EXPERIMENTAL STUDIES ON REVERSIBLE OCCLUSION IN THE MIDDLE CEREBRAL ARTERY OF RATS[J];Acta Zoologica Sinica;1993-02
2 DING Yong fang, YUAN Dong ping, FANG Tai hui (Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China);Protective Effects of Lyophilized Ginkgo biloba for Injection on Experimental Cerebral Ischemia in Mice and Rats[J];LiShiZhen Medicine and Materia Medica Research;2003-04
3 HU Xiao-song,ZHOU Dong,ZHOU De-ming.(Department of Anatomy,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China);Protective effects of PTS on cerebral ischemia-reperfusion injury in rats[J];Journal of Apoplexy and Nervous Diseases;2004-04
4 LIU Zong-chao ZHOU Guan-en ZHAO Ke-jian (Department of Neurology,The First Hospital of Jilin University,Changchun 130021,China);Protective effects of PTS on focal cerebral ischemia-reperfusion injury in rats[J];Journal of Apoplexy and Nervous Diseases;2007-01
5 Yang Shifang; Min Baozhen; Zhou Xiying (Department of pathophysiolgy, Hebei Medical Sciences College, Sigiazhuang 050021);A study on the model of focal cerebral ischemia-reperfusion in wistar rats[J];JOURNAL OF APOPLEXY AND NERVOUS DISEASES;1996-01
6 Chen Chunfu; Li Jingsong(Department of Neurology, Jinan General Hospital of PLA, Jinan 25003).;A study of focal cerebral ischemia produced by cylinder embolization in rats[J];JOURNAL OF APOPLEXY AND NERVOUS DISEASES;1996-01
7 Li Jincheng,et al;THE MODEL OF MIDDLE CEREBRAL ARTERY OCCLUSION ON SPRAGUE-DAWIEY RAT[J];Journal of Chongqing Medical University;1992-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved