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《Journal of China Medical University》 2012-02
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Effect of Shenfu Injection on MDA,SOD,TXB_2 and 6-keto-PGF1a after Cerebral Ischemia/Reperfusion Injury in Rats

JIANG Cheng-ping1,LIU Fu1,LI Yi1,WANG Bai-qiang1,TANG Xiao-rong1,WU Bi-hua2,WANG Xiao-ming2(1.Department of Pharmacology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637007,China;2.Neurology Research Institute,North Sichuan Medical College,Nanchong 637007,China)  
Objective To investigate the effect of Shenfu injection on the MDA,SOD,TXB2 and 6-keto-PGF1a after cerebral ischemia/reperfusion injury in rats.Methods Sixty male SD rats were randomly divided into three groups:Sham group(Sham group,n =20);encephalic ischemia reperfusion group(IR group,n =20) and Shenfu pretreatment group(SFI group,n =20).Reversible middle cerebral artery occlusion(MCAO) models were produced by intraluminal suture technique.The extent of neurological deficits was evaluated by Longa method;the infarct area of brain was measured by 2,3,5-triphenyl tetrazolium chloride(TTC) staining technique;while the changes of MDA,SOD,TXB2 and 6-keto-PGF1a were detected in plasma.Results Shenfu injection could effectively improve the symptoms of neurological deficits and significantly diminish the infarct areas of brain of MCAO in rats.Compared with sham operation group,MDA,TXB2 increased(P 0.05),SOD and 6-keto-PGF1a decreased(P 0.05) in IR group.Compared with IR group,MDA,TXB2 decreased(P 0.05),SOD and 6-keto-PGF1a increased in Shenfu pretreatment group(P 0.05).Conclusion Shenfu injection has a protective effect on the brain injury induced by ischemia.Its mechanism is correlated with the anti-radical effects.And it can maintain a balance between TXB2 and 6-keto-PGF1a.
【Fund】: 四川省科技厅资助项目(2010JY0094)
【CateGory Index】: R285.5
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