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Study on the percutaneous absorption of recombination human epidermal growth factor

Jiang Guohui (Jiang GH),Tang Ganghua (Tang GH),Miao Xiaochun (Miao XC),et al (Department of Nuclear Medicine,PUMC Hospital CAMS and PUMC,Beijing100730)  
OBJECTIVE:To study the absorption,permeation and metabolism of epidermal growth factor (EGF) in the surface of the skin.METHODS: 125 I EGF was labelled with Chloramine T method and a Franz diffusion cell syntem was developed for the percutaneous absorption study.The accumulated permeation amount and ratio of 125 I EGF at the different time were determined by the direct radioisotope tracing assay and the trichloroacetic acid (TCA) precipitation method.RESULTS:The total accumulated permeability ratios during 12h were all less than 1% at the different dose of 125 I EGF.There was no linearity between the dose of 125 I EGF smeared on the surface of the skin and the accumulated permeability ratio. CONCLUSION:The study provided necessary imformation for further clinical trial.
【CateGory Index】: R965
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