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Studies on paclitaxel microemulsion

Yan Jiaqi (Yan JQ),Wang Huijie (Wang HJ),Tong Yan (Tong Y),et al (Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450008)  
OBJECTIVE:To study the preparation of microemulsion containing paclitaxel for both intravenous and oral administration,its stability and bioavailability.METHODS:Corn oil was hydrated and sonicated.EPC,paclitaxel and PEG DSPE were combined in CHCl 3.A thick lipid film was obtained after drying under a stream of N 2 and vacuum evacuation.The hydrated oil was added directly to the thin phospholipid film,vortexed and then sonicated.The mixture was passed through the Microfluidizer for microemulsified.RESULTS:The particle size was 50~100 nm,the encapsulation efficiency was ≥99.2% and the absolute bioavailability of intravenous and oral adminstration was 107.7% and 22.4%,respectively.CONCLUSION:This study developed a new formulation for paclitaxel.It will provide a scientific basis of the intravenous and oral administiation of paclitaxel.
【CateGory Index】: R943
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