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《Chinese Pharmaceutical Journal》 2002-01
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Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion

CHEN Ji-wu 1,HU Tian-xi 1,ZHU Da-yuan 2 (1.School of Life Science, East China Normal University,Shanghai 200062,China;2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China)  
OBJECTIVE The structure-activity relationship of eleven pure and natural flavonoids scavenging superoxide anion (O -· 2) were studied so as to find some regularities,which may provide the foundation for their further exploitation and utility.METHODS The sensitive chemiluminescence system was used.RESULTS Nine natural flavonoids effectively scavenged O -· 2.The ability of scavenging O -· 2 in turn was:baicalinheliosinquercetinrutinhyperosidekaempferollicochalcone hesperidinnevadensin,whereas nobilitin and corylifolin-Ac did not scavenge O -· 2.CONCLUSION ①Hydroxyl groups in the A ring and/or B ring were main active groups scavenging O -· 2.②A ring and/or B ring with adjacent hydroxyl groups greatly increased their ability of scavenging O -· 2.③The hydroxyl group in the 6 position on the A ring and the hydroxyl groups in 3′?4′position on the B ring possessed the high activity of scavenging O -· 2.④The glucoside contributed to scavenge O -· 2, which varied with sort of the glucoside.⑤The phenolic hydroxyl compounds usually have activity scavenging O -· 2.
【CateGory Index】: O657.3
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