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《Chinese Pharmaceutical Journal》 2003-10
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Studies on constituents of triterpene acids from Eriobotrya japonica and their anti-inflammatory and antitussive effects

JU Jian-hua,ZHOU Liang,LIN Geng,LIU Dong,WANG Li-wei,YANG Jun-shan (Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China)  
OBJECTIVE To investigate the effective chemical constituents of traditional Chinese medicine Eriobotrya japonica .METHODS The plant material was extracted with ethanol,the extract was suspended in water,partitioned successively with petroleum ether,EtOAc,and n -BuOH.The compounds were isolated by various column chromatography and identified by their spectral data (IR,MS, 1H-NMR, 13 C-NMR) and physicochemical properties respectively.According to the clinical efficacy of E.japonica ,both anti-inflammatory and antitussive models were established for pharmacological evaluation of its fractionated extracts and constituents isolated.RESULTS The EtOAc and n-BuOH-soluble fractions were found to show an anti-inflammatory effect on xylene-induced edema in mice as well as an antitussive effect on citric acid-induced cough on guinea pigs.Phytochemical investigation of the effective n-BuOH-soluble fraction resulted in isolation of six triterpene acids,identified as oleanolic acid (Ⅰ),maslinic acid (Ⅱ),ursolic acid (Ⅲ),2α-hydroxyursolic acid (Ⅳ).Pomolic acid (Ⅴ),and euscaphic acid (Ⅵ) respectively.Pomolic acid was isolated from this plant for the first time.Ursolic acid,maslinic acid,and the total triterpene acids exhibited strong anti-inflammatory activity.Further more,Ursolic acid and the total triterpene acids also displayed antitussive activity.CONCLUSION Triterpene acid components appeared to be responsible for the pharmacological activity and clinical efficacy of E.japonica .Ursolic acid,which has a large amount,could be suitable as a significant constituent for quality control of E.japonica .
【Fund】: 国家科技部重点科技项目 (攻关 )计划 ;; 中药现代化研究与产业化开发项目—常用中药化学成分及其有效成分的研究 (No :99 92 9 0 1 3 4)资助项目
【CateGory Index】: R285
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