Research on hippocampus capsule therapy of experimental benign prostatic hyperplasia
MENG Xue-qiang~1 ,XU Dong-hui~1* ,MEI Xue-ting~1 ,XU Shi-bo~1 ,L Jun-yi~2 , LI Bing-ji~3 (1. School of Pharmaceutical Sciences,Sun Yan-sen University, Guangzhou 510275,China;2. Richvast Ocean Bio-tech Research Center of Zhongshan University, Guangzhou 510275,China;3. Guangdong Zhongda Richvast Group Co.,Ltd,Lufeng 516500,China)
OBJECTIVE To study the pharmacological effects of hippocampus capsule on experimental benign prostatic hyperplasia(BPH). METHOD The rat model was made by injecting testosterone propianate (TP) to castrated rats, the mouse model was made by transplanting urogenital sinus(UGS) to the prostates of mature male mice. RESULTS In the rat BPH model, hippocampus capsule reduced the weight and index of ventral prostate, dorsal prostate and seminal vesicle, reduced the levels of serum ACP and serum Zn, and increased the NO level in ventral prostate. In the mouse BPH model, hippocampus capsule reduced the weight and index of ventral prostate and dorsal prostate, and the levels of serum ACP and serum Zn. CONCLUSION Hippocampus capsule can be used in the treatment of experimental BPH.