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《Chinese Pharmaceutical Journal》 2005-11
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Preparation of methylphenidate hydrochloride microemulsion and its transdermal delivery effect

YU Yuan , GAO Shen , CHEN Yan, ZHONG Yan-qiang , CHENG Ming-he ( Department of Pharmaceutics , College of Phar-macy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China)  
OBJECTIVE To prepare W/O microemulsion formulation containing methylphenidate hydrochloride (MPH) and to investigate its transdermal delivery effect in vitro. METHODS The microemulsion was prepared with the system contained of isopropyl-water-lecithin-ethanol according to the phase diagram. The steady state flux and lag time of MPH were determined in vitro using Franz diffusion cell with nude rats skin. The concentration of MPH was measured by HPLC. The transdermal characteristics of MPH microemulsion across the nude rats skin were compared with control preparations. RESULTS The steady state flux of MPH microemulsion was significantly higher than the control preparations. CONCLUSION Microemulsion enhanced the penetration of MPH across nude rats skin( P 0.01).
【Fund】: 上海-SK研究与发展基金(2004011-h)
【CateGory Index】: R943
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