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《Chinese Pharmaceutical Journal》 2005-14
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Neurotrophic and neuroprotective effects of panaxynol on PC12 cells

WANG Ze-jian, CHEN Hong-zhuan, LU Yang(Institute of Materia Medica, Shanghai Second Medical University, Shanghai 200025, China)  
OBJECTIVE To investigate the neurotrophic and neuroprotective effects of panaxynol on PC12 cells.METHODS The neu-rites of PC12 and dorsal root ganglion of rats were used as screen models to study the neurotrophic and neuroprotective effects of panaxynol. RESULTS Panaxynol time-and dose-dependently promoted the neurite outgrowth and the express of the differentiation marker of PC12 cells; 8 μmol·L-1 panaxynol coordinated with 5 μg·L-1 NGF promoted the neurite outgrowth of DRG; 8 μmol·L-1 panaxynol dose-dependently protected PC12 cells from injury of NaN3. CONCLUSION It indicates that panaxynol has neurotraphic and neuroprotective effects on PC12 cells.
【Fund】: 国家自然科学基金资助项目(30371731) 上海第二医科大学-上海交通大学联合科研基金资助项目(200303HZJJ002) 上海市教委学科建设专项基金资助项目(JY2001)
【CateGory Index】: R285;
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