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《Chinese Pharmaceutical Journal》 2006-05
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Preparation of Dexamethasone Microemulsion for Ocular Application

LIN Yan-qiong~(1),GAN Yong~(2*),GAN Li~(2),WANG Bo~(3),CHEN Xin-xin~(4)(1.Nanjing Edgesword Science & Technology Co.,LTD,Nanjing 210009,China;2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;3.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China;4.Institute of Pharmacy,Zhejiang University,Hangzhou 310031,China)  
OBJECTIVE To prepare dexamethasone microemulsion for topical ocular drug delivery.METHODS Centrifuge test and the average diameter of droplet were used as the criterion to optimize the formulation and process.The optimized preparation was obtained and put into the condition of high temperature(60 ℃) or strong light(4 500±500)lx for 10 d to observe its stability.Ocular irritation test was performed in rabbits to evaluate the safety of the dexamethasone microemulsion.RESULTS Dexamethasone microemulsion for ocular appilication was stable.The average diameter of droplet was 36.8 nm.The ocular irritation test suggested that the microemulsion was safe to cornea,conjunctiva and iris.CONCLUSION Microemulsions are suitable vehicles for ocular drug delivery systems,owing to their stability,simple process and low-toxicity.
【CateGory Index】: TQ467
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