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《Chinese Pharmaceutical Journal》 2007-12
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Study on Molecular Recognition of Molecularly Imprinted Polymers with Anticholinergic Drugs as Templates

GUO Yu-shu1,XIE Jian-wei2,ZHANG Yi1(1.Navy General Hospital,Beijing 100037,China;2.Beijing Institute of Pharmacology & Toxicology,Beijing 100850,China)  
OBJECTIVE To investigate the molecular recognition mechanism of molecularly imprinted polymer(MIP) and its influence factors.METHODS MIPs were prepared with anticholinergic drug neotropine as template,methacrylic acid(MAA) as functional monomer and trimethylolpropane trimethacrylate(TRIM) as crosslinker.The specific solid phase extraction of MIPs was investigated for anticholinergic drugs:neotropine,penequinine,bencynonatine and anisodine,chlorphenamine with different hydrogen-band groups.RESULTS The results showed that the recognition ability of MIPs was associated closely with the conditions of synthesis and experiment.The specific molecular recognition was observed for anticholinergic drugs and weak adsorption for anisodine and chlorphenamine.CONCLUSION The experiments reveal that the non-specific adsorption of MIPs could mainly result from the hydrogen-band of polar groups between MIPs and analytes.The steric shape complementary between analytes and the recognition sites of MIPs plays a key role in the molecular recognition progress.
【CateGory Index】: R91
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