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Protective Effects and Mechanism of Polygonum multiflorum Thunb.Extract on Nigrostriatal Dopaminergic Neuron Lesion Induced by Paraquat

TIAN Xin1,2,LI Xia1,2,HUANG Jian-jun2,SHI Yuan2(1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.Marine College,Shandong University at Weihai,Weihai 264209,China)  
OBJECTIVE This study investigated the protective effect of Polygonum multiflorum extract(PME) on nigrostriatal dopaminergic neuron damage caused by paraquat(PQ).METHODS MTT assayed the viability of cell.HPLC analyzed the main characteristic constituents of PME.The neurons were Nissl's stained.RESULTS PQ treatment caused a reduction of the viability of cell in vitro and nigrostriatal dopaminergic neuron lesion in the striatum.Repeated administration of PME attenuated the effect of PQ cytoxcity on dopaminergic neuron lesion and the PME character consisituents is 2,3,5,4′-tetrahydroxystilbene 2-O-D-glucopyranoside.CONCLUSION The present results suggest that PME has a beneficial effect on nigrostriatal dopaminergic degeneration induced by PQ and the mechanism associated with its antioxydation.
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