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Research Progress in Chemical Constituents and Pharmacological Activities of Gynostemma pentaphyllum

FAN Dong-dong;KUANG Yan-hui;XIANG Shi-xie;ZHANG Dong;ZHU Jing-jing;WANG Zhi-min;WANG De-qin;LI Chu-yuan;Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences;Shaanxi University of Chinese Medicine;Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co.,Ltd.;  
This paper summarized the chemical constituents and pharmacological activities of Gynostemma pentaphyllum based on systematic literature research. G. pentaphyllum mainly contains dammarane-type saponins and a total of 165 gynostemma saponins were obtained from 1976 to 2011. In recent years,some new gypenosides were isolated and identified. Two hundred and one gypenosides were classified and summarized in this paper. In addition,G. pentaphyllum also contains a variety of other chemical components including flavonoids,polysaccharides,amino acids,and trace elements,which are worth further research. The pharmacological effects of G.pentaphyllum including antitumor,regulating blood lipid,hypoglycemic,liver protection,anti-senility and improving immunity effects were summarized. This review will provide some information for further research of G. pentaphyllum.
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