Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Pharmaceutical Journal》 2017-19
Add to Favorite Get Latest Update

On-line Matrix Elimination-ion Chromatography for Determination of Residual TEAB in Clopidogrel Sulfate

HUANG Qiao-qiao;HE Jia-jia;WANG Yu;Zhejiang Institute for Food and Drug Control;  
OBJECTIVE To establish a method of on-line matrix elimination together with ion chromatographic for determination of residual tetraethylammonium bromibde( TEAB) which acts as phase transfer catalyst in clopidogrel sulfate. METHODS An ion excluding column Dionex IonPac NG1 was used for the separation of TEAB from clopidogrel sulfate,using 20 mmol·L~(-1) MSA as eluent. A pre-concentration column Dionex CG17 was used to enrich the trace TEAB. After being switched to analytical system,the separation was performed on Dionex ICS3000 using Dionex IonPac CS17 as analytical column, and suppressor was not required.5 mmol·L~(-1) MSA containing 35% acetonitrile was used as mobile phase. RESULTS The RSDs of retention time and peak area were good. The recoveries of TEAB were between 97. 8%~(-1)03. 3%. The calibration curves of analytes were linear in the range between 0. 4 and 10. 0 μg·mL~(-1). The limit of detection reached 0. 2 μg·mL~(-1). CONCLUSION This method can be applied to detect trace kation in pharmaceutical chemicals.
【Fund】: 浙江省公益技术应用研究(分析测试)项目资助(2016C37020)
【CateGory Index】: O657.7;R927
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved