Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Hospital Pharmacy》 2004-02
Add to Favorite Get Latest Update

Determination of ornidazole concentration in breast milk by RP-HPLC

LAN Shun,YE Dong-Mei,FAN Lu-Lin(People's Hospital of GuangXi Zhuang Automatic Region,Guangxi Nanning 530021,China)  
OBJECTIVE To establish a method for determining the concentration of ornidazole in breast milk by RP-HPLC.METHODS Nova-Pak C 18 column as stationary phase, methanol-water(30∶70) as mobile phase with the flow rate of 0.8 mL ·min -1 .The temperature of column was at 25℃,the wavelength of detection was 318nm .Ornidazole was extracted from breast milk with chloroform-propanol and soluted in mobile phase. RESULTS The calibration curve was linear within the concentration range of 1.96 ~ 29.40 mg ·L -1 , r = 0.9994 ,the limit of detection was 0.16 mg ·L -1 ,the average recovery was( 99.7 ± 0.6 )%,and the RSD values of within-day and between days did not exceed 4.8% and 4.9% ,respectively.CONCLUSIONS The method is accurate,sensitive,precise and usable for pharmacokinetic study of ornidazole in breast milk.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 LI Qin1WANG Ben-Jie2GUO Rui-Chen21(Dept. of Pharmacology,Liaocheng People Hospital,Liaocheng, 252000)2(Institute of ClinicalPharmacology, Qilu Hospital,Shandong University, Jinan,250012);Study of the Pharmacokinetics and Bioequivalance of Ornidazole Capsules andImported Ornidazole Tablets in Healthy Volunteers[J];The Chinese Journal of Clinical Pharmacology;2002-02
2 DAI Yinmei, ZHANG Hong, WANG Xiuhua. Department of Obstertics and Gyanecology, The First Affiliated Hospital of Lanzhou Medical College ,Lanzhou 730000,China;Pharmacokinetics of Metronidazole and Tinidazole in Human Dreast and the Effects on Dreast-fed Infants[J];Chinese Journal of Perinatal Medicine;2002-01
3 Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang-ying-yuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)Xu Zheng;Qian Yu-yin;Xia Yian-ping and LiQiao-yun(Obstetrics and Gynecology Hospital,Shanghai Medical Unive;STUDY ON CLINICAL PHARMACOLOGY OF METRONIDAZOLE IN PREGNNT AND BREAST-FEEDING WOMEN[J];CHINESE JOURNAL OF NATIBIOTICS;1994-01
4 TANG Hui-fang~1,GONG Pei-li~1,ZHOU Ji-an~1,LI Ying-qian~1,ZHENG Q i-chang~2, DAI Li-ren~2,MIN Jie~2,LI Xing-rui~3, PENG Zhi-xiang~3,CHEN Ru~3, DING Jun-qing~4, LUO Xin~4,WANG Pei-liang~5,PU Zi-jing~5,YANG Heng~5 (1.Institute of Clinical Pharmacology,;The multi-center clinical study of the efficacy of ornidazole against acute anaerobic infections and vaginalis trichomoniasis[J];Chinese New Drugs Journal;2001-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 QIU Xin-feng(Anqing Municipal Hopsital,Anqing 246003,China);Preparation and quality control of ornidazole aphthae liquor[J];Anhui Medical and Pharmaceutical Journal;2005-12
2 GUO Xian-xi~1,LIU Hai-tao~2,LUO Yun~1,WANG Fang~1,SONG Jin-chun~1(Department of Pharmacy,People's Hospital of Wuhan University,Wuhan 430060, China);Pharmacokinetics of ornidazole injection in rabbits[J];Journal of Guangdong College of Pharmacy;2005-06
3 WU Mei-xiang OUYANG Ji-de Chenzhou Institute for Drug Control,Chenzhou 423000 Hunan China;The formulation of metronidazole suppositories by HPLC[J];International Medicine & Health Guidance News;2008-20
4 LIU Hong-wei1,CAI Ya-xi1,BI Shi-liang1,HU Li-na1,DONG Xiao-jing2,CHEN Lian3,YANG Ye-zhou3,LIANG Jia-zhi4,XIAO Bing4(1.Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu 610041,China;2.No.2 Hospital of Congqing Medical University,Chongqing 400010,China;3.The Plople's Hospital of Sichuan Province,Chengdu 610072,China;4.Sichuan Provincial Hospital for Women and Children,Chengdu 610031,China);Randomized,double-blind,controlled,multicenter clinical trial of ornidazole suppositories in the treatment of trichomonal vaginitis[J];The Chinese Journal of Clinical Pharmacology;2008-03
5 MAO Wei-Dan,LIANG Fei-fei,SUN Betty,et al.Guangxi Medical University,a clinical 2004 class 9 Nanning 530021,China.;Comparative observation on the effects of three drugs on Trichomonas vaginalis in vitro[J];Journal of Applied Preventive Medicine;2008-04
6 Wu Mei-xiang,OU YANG Ji-de,Tan Zhi-yan.Chenzhou institute for drug control in Hunan province,Chenzhou 423000,China;HPLC simultaneous determination of the four nitroimidazoles formulation[J];International Medicine & Health Guidance News;2009-17
7 JIANG Qiyu,LIU Jie,GU Haiying(School of Public Health, Nantong University, Jiangsu 226007);The electrochemical behavior of Ornidazole on pretreated glassy carbon electrode and its trace determination[J];Medical Journal of Communications;2008-06
8 Tang Ming, Xiao Xiaorong, Zhang Jincai, et al. The First Affiliated Hospital, Chongaing University of Medicial Science, Chongqing 400016, China;The comparision of antibacterial activities of 3 nitroimidazoles against the periodontal pathogen[J];Journal of Clinical Stomatology;2002-05
9 LU Hao _ jie, ZHANG Hong, RUAN Zong _ qin, OU Qing _ yu(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China);Study on the Pharmacokinetics of Metronidazole in Human Milk by Capillary Electrophoresis[J];JOURNAL OF INSTRUMENTAL ANALYSIS;2000-04
10 QI Jin-wen~(1),MA Ke~(1),WU Yuan-hang~(2)(1.Department of Pharmacy,Zhejiang Provincial People's Hospital,Hangzhou 310014,China;2.City College,Zhejiang University,Hangzhou 310015,China);Permeability of ornidazole through blood-pancreatic barrier in rats[J];Chinese Journal of Modern Applied Pharmacy;2006-05
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Bi-mei, WANG Chang-li, PENG Jun, JIANG Hong, LI Zeng-yan (Department of Pharmacy, General Hospital of Tianjin Medical University, Tianjin 300052, China; Department of Obstetrics & Gynecology, General Hospital of Tianjin Medical University, Tianjin 300052, China);Study on the determination of tinidazole in breast milk[J];Chinese Pharmaceutical Journal;2004-11
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Wei Yuying;Wu Xirui;Xiao Dunzhen et al(Family Planning Research Institute, Tongji Medical University,Wuhan 430030);The Clinical Observation on the Therapeutic Effect of Tinidazole on Trichomonus Vaginitis[J];ACTAUNIVERSITATIS MEDICTNAE TANGJI;1995-02
2 WangRenfei*,ChenLili,NiKefu,etal.*DepartmentofStomatology,ZhejiangProvincialPeople′sHospital,Hangzhou310014;Theeffectoftinidazoleinthetreatmentofadultperiodontitis[J];CHINESE JOURNAL OF STOMATOLOGY;1996-05
3 Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang-ying-yuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)Xu Zheng;Qian Yu-yin;Xia Yian-ping and LiQiao-yun(Obstetrics and Gynecology Hospital,Shanghai Medical Unive;STUDY ON CLINICAL PHARMACOLOGY OF METRONIDAZOLE IN PREGNNT AND BREAST-FEEDING WOMEN[J];CHINESE JOURNAL OF NATIBIOTICS;1994-01
4 Tang Hanxiang (Division of Clinical Pharmacy,The First Municipal Hospital of Yueyang,Hunan Province,414000);CLINICAL PHARMACOLOGY OF TINIDAZOLE[J];CHINESE NEW DRUGS JOURNAL;1997-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved